Smooth nonparametric maximum likelihood estimation for population pharmacokinetics, with application to quinidine.
Journal Article (Journal Article)
The seminonparametric (SNP) method, popular in the econometrics literature, is proposed for use in population pharmacokinetic analysis. For data that can be described by the nonlinear mixed effects model, the method produces smooth nonparametric estimates of the entire random effects density and simultaneous estimates of fixed effects by maximum likelihood. A graphical model-building strategy based on the SNP method is described. The methods are illustrated by a population analysis of plasma levels in 136 patients undergoing oral quinidine therapy.
Full Text
Duke Authors
Cited Authors
- Davidian, M; Gallant, AR
Published Date
- October 1992
Published In
Volume / Issue
- 20 / 5
Start / End Page
- 529 - 556
PubMed ID
- 1287201
International Standard Serial Number (ISSN)
- 0090-466X
Digital Object Identifier (DOI)
- 10.1007/BF01061470
Language
- eng
Conference Location
- United States