Centralized immunogens as a vaccine strategy to overcome HIV-1 diversity


Journal Article (Review)

Genetic variation of HIV-1 represents a major obstacle for AIDS vaccine development. With the amino acid sequence divergence as high as 30% in envelopes between different subtypes among HIV-1 group M viruses, it is unlikely that cross-subtype protection will occur equally well among all subtypes. Computer programs have been used to generate 'centralized' HIV gene sequences: consensus, ancestor or center of the free. These sequences can decrease the genetic distances between the 'centralized' and wild-type gene immunogens to half of those between any wild-type immuongens to each other, Recent studies demonstrated that an artificial group M consensus env gene is equidistant from any subtype and recombinants. It is biologically functional and preserves antigenicity similar to contemporary Env proteins. Most importantly, the group M consensus Env immunogen can elicit both T- and B-cell responses to wild-type HIV-1 isolates.

Full Text

Duke Authors

Cited Authors

  • Gao, F; Korber, BT; Weaver, EA; Liao, HX; Hahn, BH; Haynes, BF

Published Date

  • August 1, 2004

Published In

Volume / Issue

  • 3 / 4 SUPPL.

International Standard Serial Number (ISSN)

  • 1476-0584

Digital Object Identifier (DOI)

  • 10.1586/14760584.3.4.S161

Citation Source

  • Scopus