Comparative analysis of commercial assays for the detection and quantification of Human Immunodeficiency Virus Type 1 (HIV-1) RNA in plasma from patients infected with HIV-1 subtype C.

Journal Article

The commercial assays commonly used to quantify plasma human immunodeficiency virus type 1 (HIV-1) RNA in clinical settings were designed to assess HIV-1 subtype B. We compared the performance of 4 commercial assays (Amplicor versions 1.0 and 1.5 [Roche]; Quantiplex [Chiron]; and NASBA HIV-1 RNA QT [Organon Teknika]) in detecting and quantifying HIV-1 RNA in plasma from HIV-infected persons from Zambia, an area where HIV-1 subtype C is predominant. Each assay detected plasma HIV-1 RNA, but they do not all measure statistically similar quantities of plasma HIV-1 RNA.

Full Text

Duke Authors

Cited Authors

  • Hoesley, CJ; Allen, SA; Raper, JL; Musonda, R; Niu, Y; Gao, F; Squires, KE; Aldrovandi, GM

Published Date

  • August 1, 2002

Published In

Volume / Issue

  • 35 / 3

Start / End Page

  • 323 - 325

PubMed ID

  • 12115099

Pubmed Central ID

  • 12115099

Electronic International Standard Serial Number (EISSN)

  • 1537-6591

Digital Object Identifier (DOI)

  • 10.1086/341490


  • eng

Conference Location

  • United States