Timing the ancestor of the HIV-1 pandemic strains.

Published

Journal Article

HIV-1 sequences were analyzed to estimate the timing of the ancestral sequence of the main group of HIV-1, the strains responsible for the AIDS pandemic. Using parallel supercomputers and assuming a constant rate of evolution, we applied maximum-likelihood phylogenetic methods to unprecedented amounts of data for this calculation. We validated our approach by correctly estimating the timing of two historically documented points. Using a comprehensive full-length envelope sequence alignment, we estimated the date of the last common ancestor of the main group of HIV-1 to be 1931 (1915-41). Analysis of a gag gene alignment, subregions of envelope including additional sequences, and a method that relaxed the assumption of a strict molecular clock also supported these results.

Full Text

Duke Authors

Cited Authors

  • Korber, B; Muldoon, M; Theiler, J; Gao, F; Gupta, R; Lapedes, A; Hahn, BH; Wolinsky, S; Bhattacharya, T

Published Date

  • June 2000

Published In

Volume / Issue

  • 288 / 5472

Start / End Page

  • 1789 - 1796

PubMed ID

  • 10846155

Pubmed Central ID

  • 10846155

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.288.5472.1789

Language

  • eng