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International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma.

Publication ,  Journal Article
Lokhorst, H; Einsele, H; Vesole, D; Bruno, B; San Miguel, J; Pérez-Simon, JA; Kröger, N; Moreau, P; Gahrton, G; Gasparetto, C; Giralt, S ...
Published in: J Clin Oncol
October 10, 2010

PURPOSE: To define consensus statement regarding allogeneic stem-cell transplantation (Allo-SCT) as a treatment option for multiple myeloma (MM) on behalf of International Myeloma Working Group. PATIENTS AND METHODS: In this review, results from prospective and retrospective studies of Allo-SCT in MM are summarized. RESULTS: Although the introduction of reduced-intensity conditioning (RIC) has lowered the high treatment-related mortality associated with myeloablative conditioning, convincing evidence is lacking that Allo-RIC improves the survival compared with autologous stem-cell transplantation. CONCLUSION: New strategies are necessary to make Allo-SCT safer and more effective for patients with MM. Until this is achieved, Allo-RIC in myeloma should only be recommended in the context of clinical trials.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

October 10, 2010

Volume

28

Issue

29

Start / End Page

4521 / 4530

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Conditioning
  • Oncology & Carcinogenesis
  • Multiple Myeloma
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Disease-Free Survival
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

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Lokhorst, H., Einsele, H., Vesole, D., Bruno, B., San Miguel, J., Pérez-Simon, J. A., … International Myeloma Working Group, . (2010). International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma. J Clin Oncol, 28(29), 4521–4530. https://doi.org/10.1200/JCO.2010.29.7929
Lokhorst, Henk, Hermann Einsele, David Vesole, Benedetto Bruno, Jesus San Miguel, Jose A. Pérez-Simon, Nicolaus Kröger, et al. “International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma.J Clin Oncol 28, no. 29 (October 10, 2010): 4521–30. https://doi.org/10.1200/JCO.2010.29.7929.
Lokhorst H, Einsele H, Vesole D, Bruno B, San Miguel J, Pérez-Simon JA, et al. International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma. J Clin Oncol. 2010 Oct 10;28(29):4521–30.
Lokhorst, Henk, et al. “International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma.J Clin Oncol, vol. 28, no. 29, Oct. 2010, pp. 4521–30. Pubmed, doi:10.1200/JCO.2010.29.7929.
Lokhorst H, Einsele H, Vesole D, Bruno B, San Miguel J, Pérez-Simon JA, Kröger N, Moreau P, Gahrton G, Gasparetto C, Giralt S, Bensinger W, International Myeloma Working Group. International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma. J Clin Oncol. 2010 Oct 10;28(29):4521–4530.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

October 10, 2010

Volume

28

Issue

29

Start / End Page

4521 / 4530

Location

United States

Related Subject Headings

  • Transplantation, Homologous
  • Transplantation Conditioning
  • Oncology & Carcinogenesis
  • Multiple Myeloma
  • Humans
  • Hematopoietic Stem Cell Transplantation
  • Disease-Free Survival
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences