International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma.

Published

Journal Article

PURPOSE: To define consensus statement regarding allogeneic stem-cell transplantation (Allo-SCT) as a treatment option for multiple myeloma (MM) on behalf of International Myeloma Working Group. PATIENTS AND METHODS: In this review, results from prospective and retrospective studies of Allo-SCT in MM are summarized. RESULTS: Although the introduction of reduced-intensity conditioning (RIC) has lowered the high treatment-related mortality associated with myeloablative conditioning, convincing evidence is lacking that Allo-RIC improves the survival compared with autologous stem-cell transplantation. CONCLUSION: New strategies are necessary to make Allo-SCT safer and more effective for patients with MM. Until this is achieved, Allo-RIC in myeloma should only be recommended in the context of clinical trials.

Full Text

Duke Authors

Cited Authors

  • Lokhorst, H; Einsele, H; Vesole, D; Bruno, B; San Miguel, J; Pérez-Simon, JA; Kröger, N; Moreau, P; Gahrton, G; Gasparetto, C; Giralt, S; Bensinger, W; International Myeloma Working Group,

Published Date

  • October 10, 2010

Published In

Volume / Issue

  • 28 / 29

Start / End Page

  • 4521 - 4530

PubMed ID

  • 20697091

Pubmed Central ID

  • 20697091

Electronic International Standard Serial Number (EISSN)

  • 1527-7755

Digital Object Identifier (DOI)

  • 10.1200/JCO.2010.29.7929

Language

  • eng

Conference Location

  • United States