International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma.
Published
Journal Article
PURPOSE: To define consensus statement regarding allogeneic stem-cell transplantation (Allo-SCT) as a treatment option for multiple myeloma (MM) on behalf of International Myeloma Working Group. PATIENTS AND METHODS: In this review, results from prospective and retrospective studies of Allo-SCT in MM are summarized. RESULTS: Although the introduction of reduced-intensity conditioning (RIC) has lowered the high treatment-related mortality associated with myeloablative conditioning, convincing evidence is lacking that Allo-RIC improves the survival compared with autologous stem-cell transplantation. CONCLUSION: New strategies are necessary to make Allo-SCT safer and more effective for patients with MM. Until this is achieved, Allo-RIC in myeloma should only be recommended in the context of clinical trials.
Full Text
Duke Authors
Cited Authors
- Lokhorst, H; Einsele, H; Vesole, D; Bruno, B; San Miguel, J; Pérez-Simon, JA; Kröger, N; Moreau, P; Gahrton, G; Gasparetto, C; Giralt, S; Bensinger, W; International Myeloma Working Group,
Published Date
- October 10, 2010
Published In
Volume / Issue
- 28 / 29
Start / End Page
- 4521 - 4530
PubMed ID
- 20697091
Pubmed Central ID
- 20697091
Electronic International Standard Serial Number (EISSN)
- 1527-7755
Digital Object Identifier (DOI)
- 10.1200/JCO.2010.29.7929
Language
- eng
Conference Location
- United States