Effects of hematopoietic growth factors following myeloablation in a primate model.
Journal Article (Journal Article)
The complex effects of hematopoietic growth factors (granulocyte and granulocyte-macrophage colony-stimulating factors and interleukin 3 and interleukin 1 beta) following myeloablation in juvenile male cynomolgus monkeys was studied. Since the effects of a given cytokine in vivo do not necessarily reflect the in vitro situation, and since cytokines are frequently species specific, extrapolation from rodent models to man may be fraught with inaccuracies. A primate model, therefore, was developed which has provided useful preclinical information on hematopoietic responses, dose response relationships and toxicities associated with administration of recombinant hematopoietic growth factors. This information has direct application to human trials.
Full Text
Duke Authors
Cited Authors
- O'Reilly, RJ; Gillio, A; Gasparetto, C
Published Date
- January 1990
Published In
Volume / Issue
- 8 Suppl 1 /
Start / End Page
- 262 - 267
PubMed ID
- 1691247
International Standard Serial Number (ISSN)
- 0737-1454
Digital Object Identifier (DOI)
- 10.1002/stem.5530080724
Language
- eng
Conference Location
- United States