Spatial heterogeneity of restitution properties and the onset of alternans.

Journal Article (Journal Article)

Traditionally, it was believed that cardiac rhythm stability was governed by the slope of the restitution curve (RC), which relates the duration of an action potential to the preceding diastolic interval. However, a single RC does not exist; rate-dependence leads to multiple distinct RCs. We measure spatial differences in the steady-state action potential duration (APD), as well as in three different RCs: the S1-S2 (SRC), constant-basic-cycle-length (BRC), and dynamic (DRC), and correlate these differences with the tissue's propensity to develop alternans. The results show that spatial differences in APD, SRC slope, and DRC slope are correlated with the tissue's propensity to exhibit alternans. These results may lead to a new diagnostic approach to identifying patients with vulnerability to arrhythmias, which will involve pacing at slow rates and analyzing spatial differences in restitution properties.

Full Text

Duke Authors

Cited Authors

  • Dobrovolny, HM; Berger, CM; Brown, NH; Neu, WK; Gauthier, DJ

Published Date

  • January 2009

Published In

  • Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference

Volume / Issue

  • 2009 /

Start / End Page

  • 4186 - 4189

PubMed ID

  • 19964626

Electronic International Standard Serial Number (EISSN)

  • 2694-0604

International Standard Serial Number (ISSN)

  • 2375-7477

Digital Object Identifier (DOI)

  • 10.1109/iembs.2009.5333929


  • eng