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Transitions between 2:1 and 1:1 responses in cardiac muscle induced by added stimuli

Publication ,  Journal Article
Bahar, S; Hall, GM; Oliver, RA; Krassowska, W; Gauthier, DJ
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
December 1, 1999

We demonstrate experimentally that transitions can be induced between stable coexisting response patterns in bullfrog ventricular myocardium by means of a single pulse injected into the stimulus train. We find that two distinct ranges of stimulus timings will elicit transitions from a 1:1 state, in which one stimulus elicits one response, and a 2:1 state, in which every other stimulus elicits a response. We also observe two distinct types of 2:1→1:1 transition. These transitions are differentiated by their transient behavior while settling from one stable state into another. We characterize these transitions, and the ranges of added stimulus timings which produce them, both experimentally and with two simple models of cardiac dynamics.

Duke Scholars

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ISSN

0589-1019

Publication Date

December 1, 1999

Volume

1

Start / End Page

258
 

Citation

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Bahar, S., Hall, G. M., Oliver, R. A., Krassowska, W., & Gauthier, D. J. (1999). Transitions between 2:1 and 1:1 responses in cardiac muscle induced by added stimuli. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 1, 258.
Bahar, S., G. M. Hall, R. A. Oliver, W. Krassowska, and D. J. Gauthier. “Transitions between 2:1 and 1:1 responses in cardiac muscle induced by added stimuli.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings 1 (December 1, 1999): 258.
Bahar S, Hall GM, Oliver RA, Krassowska W, Gauthier DJ. Transitions between 2:1 and 1:1 responses in cardiac muscle induced by added stimuli. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999 Dec 1;1:258.
Bahar, S., et al. “Transitions between 2:1 and 1:1 responses in cardiac muscle induced by added stimuli.” Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 1, Dec. 1999, p. 258.
Bahar S, Hall GM, Oliver RA, Krassowska W, Gauthier DJ. Transitions between 2:1 and 1:1 responses in cardiac muscle induced by added stimuli. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 1999 Dec 1;1:258.

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ISSN

0589-1019

Publication Date

December 1, 1999

Volume

1

Start / End Page

258