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ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for urothelial carcinoma-neoadjuvant and adjuvant settings.

Publication ,  Journal Article
Sternberg, CN; Bellmunt, J; Sonpavde, G; Siefker-Radtke, AO; Stadler, WM; Bajorin, DF; Dreicer, R; George, DJ; Milowsky, MI; Theodorescu, D ...
Published in: Eur Urol
January 2013

CONTEXT: We present a summary of the Second International Consultation on Bladder Cancer recommendations on chemotherapy for the treatment of bladder cancer using an evidence-based strategy. OBJECTIVE: To review the data regarding chemotherapy in patients with clinically localized and metastatic bladder cancer with a focus on its use for patients in the neoadjuvant and adjuvant settings. EVIDENCE ACQUISITION: Medline databases were searched for original articles published prior to April 1, 2012, using the following search terms: bladder cancer, urothelial cancer, metastatic, advanced, neoadjuvant, and adjuvant therapy. Proceedings of major conferences from the last 5 yr also were searched. Novel and promising drugs currently in clinical trials were included. EVIDENCE SYNTHESIS: The major findings are addressed in an evidence-based manner. Prospective trials and important cohort data were analyzed. CONCLUSIONS: Cisplatin-based combination chemotherapy for advanced and metastatic bladder cancer is an established standard, improving overall survival. In the advanced setting, cisplatin-ineligible patients may benefit from gemcitabine and carboplatin. Meta-analyses undertaken for neoadjuvant cisplatin-based combination chemotherapy show a 5% benefit in overall survival. Pathologic complete remission may be an intermediate surrogate for survival, but requires further validation. Use of neoadjuvant chemotherapy is low, and is attributable to patient and physician choice because of limited benefit, advanced age, and comorbidities including renal and/or cardiac dysfunction. Sufficient data to support adjuvant chemotherapy are lacking.

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Published In

Eur Urol

DOI

EISSN

1873-7560

Publication Date

January 2013

Volume

63

Issue

1

Start / End Page

58 / 66

Location

Switzerland

Related Subject Headings

  • Urothelium
  • Urology & Nephrology
  • Urinary Bladder Neoplasms
  • Treatment Outcome
  • Neoadjuvant Therapy
  • Humans
  • Chemotherapy, Adjuvant
  • Carcinoma
  • Antineoplastic Combined Chemotherapy Protocols
  • 3202 Clinical sciences
 

Citation

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Sternberg, C. N., Bellmunt, J., Sonpavde, G., Siefker-Radtke, A. O., Stadler, W. M., Bajorin, D. F., … International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012, . (2013). ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for urothelial carcinoma-neoadjuvant and adjuvant settings. Eur Urol, 63(1), 58–66. https://doi.org/10.1016/j.eururo.2012.08.010
Sternberg, Cora N., Joaquim Bellmunt, Guru Sonpavde, Arlene O. Siefker-Radtke, Walter M. Stadler, Dean F. Bajorin, Robert Dreicer, et al. “ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for urothelial carcinoma-neoadjuvant and adjuvant settings.Eur Urol 63, no. 1 (January 2013): 58–66. https://doi.org/10.1016/j.eururo.2012.08.010.
Sternberg CN, Bellmunt J, Sonpavde G, Siefker-Radtke AO, Stadler WM, Bajorin DF, et al. ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for urothelial carcinoma-neoadjuvant and adjuvant settings. Eur Urol. 2013 Jan;63(1):58–66.
Sternberg, Cora N., et al. “ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for urothelial carcinoma-neoadjuvant and adjuvant settings.Eur Urol, vol. 63, no. 1, Jan. 2013, pp. 58–66. Pubmed, doi:10.1016/j.eururo.2012.08.010.
Sternberg CN, Bellmunt J, Sonpavde G, Siefker-Radtke AO, Stadler WM, Bajorin DF, Dreicer R, George DJ, Milowsky MI, Theodorescu D, Vaughn DJ, Galsky MD, Soloway MS, Quinn DI, International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012. ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for urothelial carcinoma-neoadjuvant and adjuvant settings. Eur Urol. 2013 Jan;63(1):58–66.
Journal cover image

Published In

Eur Urol

DOI

EISSN

1873-7560

Publication Date

January 2013

Volume

63

Issue

1

Start / End Page

58 / 66

Location

Switzerland

Related Subject Headings

  • Urothelium
  • Urology & Nephrology
  • Urinary Bladder Neoplasms
  • Treatment Outcome
  • Neoadjuvant Therapy
  • Humans
  • Chemotherapy, Adjuvant
  • Carcinoma
  • Antineoplastic Combined Chemotherapy Protocols
  • 3202 Clinical sciences