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Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma.

Publication ,  Journal Article
Bhatt, RS; Zurita, AJ; O'Neill, A; Norden-Zfoni, A; Zhang, L; Wu, HK; Wen, PY; George, D; Sukhatme, VP; Atkins, MB; Heymach, JV
Published in: Br J Cancer
June 28, 2011

BACKGROUND: Circulating endothelial cells (CECs) are a candidate biomarker for monitoring angiogenesis in cancer. Circulating endothelial cell subsets are mobilised by angiogenic mediators. Because of the highly angiogenic phenotype of renal cell carcinoma (RCC), we sought to assess the potential of CECs as a marker of RCC in patients with von Hippel-Lindau (VHL) disease and those with sporadic RCC. METHODS: We performed multicolour flow cytometry to enumerate CECs in patients with RCC, patients with VHL disease with and without RCC, and normal subjects. Two subsets of CECs were evaluated: mature CECs (mCECs) and circulating endothelial progenitors (CEPs). RESULTS: In patients with VHL disease and RCC and those with sporadic RCC (N=10), CEPs and the CEP:mCEC ratio were higher than in normal subjects (N=17) (median CEPs: 0.97 vs 0.19 cells μl(-1), respectively, P<0.01; median CEP:mCEC: 0.92 vs 0.58, respectively, P=0.04). However, in patients with VHL without RCC, CECs were not increased. In paired pre- and post-nephrectomy RCC patient samples (N=20), CEPs decreased after surgery (median difference 0.02 cells μl(-1), -0.06 to 1.2; P=0.05). CONCLUSION: Circulating endothelial progenitors were elevated in RCC, but not in patients with VHL without RCC. Circulating endothelial progenitor enumeration merits further investigation as a monitoring strategy for patients with VHL.

Duke Scholars

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

June 28, 2011

Volume

105

Issue

1

Start / End Page

112 / 117

Location

England

Related Subject Headings

  • von Hippel-Lindau Disease
  • Treatment Outcome
  • Survival Rate
  • Oncology & Carcinogenesis
  • Neoplastic Stem Cells
  • Kidney Neoplasms
  • Humans
  • Hematopoietic Stem Cell Mobilization
  • Endothelial Cells
  • Case-Control Studies
 

Citation

APA
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ICMJE
MLA
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Bhatt, R. S., Zurita, A. J., O’Neill, A., Norden-Zfoni, A., Zhang, L., Wu, H. K., … Heymach, J. V. (2011). Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma. Br J Cancer, 105(1), 112–117. https://doi.org/10.1038/bjc.2011.186
Bhatt, R. S., A. J. Zurita, A. O’Neill, A. Norden-Zfoni, L. Zhang, H. K. Wu, P. Y. Wen, et al. “Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma.Br J Cancer 105, no. 1 (June 28, 2011): 112–17. https://doi.org/10.1038/bjc.2011.186.
Bhatt RS, Zurita AJ, O’Neill A, Norden-Zfoni A, Zhang L, Wu HK, et al. Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma. Br J Cancer. 2011 Jun 28;105(1):112–7.
Bhatt, R. S., et al. “Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma.Br J Cancer, vol. 105, no. 1, June 2011, pp. 112–17. Pubmed, doi:10.1038/bjc.2011.186.
Bhatt RS, Zurita AJ, O’Neill A, Norden-Zfoni A, Zhang L, Wu HK, Wen PY, George D, Sukhatme VP, Atkins MB, Heymach JV. Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma. Br J Cancer. 2011 Jun 28;105(1):112–117.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

June 28, 2011

Volume

105

Issue

1

Start / End Page

112 / 117

Location

England

Related Subject Headings

  • von Hippel-Lindau Disease
  • Treatment Outcome
  • Survival Rate
  • Oncology & Carcinogenesis
  • Neoplastic Stem Cells
  • Kidney Neoplasms
  • Humans
  • Hematopoietic Stem Cell Mobilization
  • Endothelial Cells
  • Case-Control Studies