Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement.

Journal Article (Journal Article)

This study analyzed the T2* effect of extracellularly distributed gadolinium contrast agents in arterial blood during tumor studies using T1-weighted sequences at high field strength. A saturation-prepared dual echo sequence with echo times of 1.5 and 3.5 ms was employed at 3 T to simultaneously characterize T1 and T2* of arterial blood during bolus administration of Gd-DTPA in 28 patients with body tumors. T2* effect and T1 effect of Gd-DTPA on image intensity of whole blood were calibrated in human blood samples with different concentrations of contrast agent. T2* was used to estimate concentration near the peak of the bolus. T1 was used to measure lower concentrations when T2* was not significant. T2* was measurable on calibration curves for Gd-DTPA concentrations higher than 4 mM. This concentration was exceeded in 18 patients. The mean signal intensity reduction because of T2* effect was estimated at 22+/-14% of the T2* compensated signal. Using T2* measurements reduced underestimations of peak arterial Gd-DTPA concentration (59 +/- 38%) and overestimation of permeability Ktrans (58%). The T2* effect of gadolinium contrast agents should therefore be accounted for when performing tumors study with T1-weighted sequences at high field strength.

Full Text

Duke Authors

Cited Authors

  • de Bazelaire, C; Rofsky, NM; Duhamel, G; Zhang, J; Michaelson, MD; George, D; Alsop, DC

Published Date

  • September 2006

Published In

Volume / Issue

  • 16 / 9

Start / End Page

  • 2083 - 2091

PubMed ID

  • 16583215

International Standard Serial Number (ISSN)

  • 0938-7994

Digital Object Identifier (DOI)

  • 10.1007/s00330-006-0198-1


  • eng

Conference Location

  • Germany