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Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement.

Publication ,  Journal Article
de Bazelaire, C; Rofsky, NM; Duhamel, G; Zhang, J; Michaelson, MD; George, D; Alsop, DC
Published in: Eur Radiol
September 2006

This study analyzed the T2* effect of extracellularly distributed gadolinium contrast agents in arterial blood during tumor studies using T1-weighted sequences at high field strength. A saturation-prepared dual echo sequence with echo times of 1.5 and 3.5 ms was employed at 3 T to simultaneously characterize T1 and T2* of arterial blood during bolus administration of Gd-DTPA in 28 patients with body tumors. T2* effect and T1 effect of Gd-DTPA on image intensity of whole blood were calibrated in human blood samples with different concentrations of contrast agent. T2* was used to estimate concentration near the peak of the bolus. T1 was used to measure lower concentrations when T2* was not significant. T2* was measurable on calibration curves for Gd-DTPA concentrations higher than 4 mM. This concentration was exceeded in 18 patients. The mean signal intensity reduction because of T2* effect was estimated at 22+/-14% of the T2* compensated signal. Using T2* measurements reduced underestimations of peak arterial Gd-DTPA concentration (59 +/- 38%) and overestimation of permeability Ktrans (58%). The T2* effect of gadolinium contrast agents should therefore be accounted for when performing tumors study with T1-weighted sequences at high field strength.

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Published In

Eur Radiol

DOI

ISSN

0938-7994

Publication Date

September 2006

Volume

16

Issue

9

Start / End Page

2083 / 2091

Location

Germany

Related Subject Headings

  • Phantoms, Imaging
  • Permeability
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Angiography
  • Lung Neoplasms
  • Image Enhancement
  • Humans
  • Gadolinium DTPA
  • Contrast Media
  • Carcinoma, Renal Cell
 

Citation

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de Bazelaire, C., Rofsky, N. M., Duhamel, G., Zhang, J., Michaelson, M. D., George, D., & Alsop, D. C. (2006). Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement. Eur Radiol, 16(9), 2083–2091. https://doi.org/10.1007/s00330-006-0198-1
Bazelaire, Cedric de, Neil M. Rofsky, Guillaume Duhamel, Jingbo Zhang, M Dror Michaelson, Daniel George, and David C. Alsop. “Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement.Eur Radiol 16, no. 9 (September 2006): 2083–91. https://doi.org/10.1007/s00330-006-0198-1.
de Bazelaire C, Rofsky NM, Duhamel G, Zhang J, Michaelson MD, George D, et al. Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement. Eur Radiol. 2006 Sep;16(9):2083–91.
de Bazelaire, Cedric, et al. “Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement.Eur Radiol, vol. 16, no. 9, Sept. 2006, pp. 2083–91. Pubmed, doi:10.1007/s00330-006-0198-1.
de Bazelaire C, Rofsky NM, Duhamel G, Zhang J, Michaelson MD, George D, Alsop DC. Combined T2* and T1 measurements for improved perfusion and permeability studies in high field using dynamic contrast enhancement. Eur Radiol. 2006 Sep;16(9):2083–2091.
Journal cover image

Published In

Eur Radiol

DOI

ISSN

0938-7994

Publication Date

September 2006

Volume

16

Issue

9

Start / End Page

2083 / 2091

Location

Germany

Related Subject Headings

  • Phantoms, Imaging
  • Permeability
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Angiography
  • Lung Neoplasms
  • Image Enhancement
  • Humans
  • Gadolinium DTPA
  • Contrast Media
  • Carcinoma, Renal Cell