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Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1).

Publication ,  Journal Article
De Bazelaire, C; Rofsky, NM; Duhamel, G; Michaelson, MD; George, D; Alsop, DC
Published in: Acad Radiol
March 2005

RATIONALE AND OBJECTIVE: This study sought to assess the feasibility of arterial spin labeling (ASL) blood flow (BF) magnetic resonance imaging (MRI) for the study of metastatic renal cell carcinoma (RCC) in the body, where the respiratory, cardiac, and peristaltic motions present challenges when applying ASL. MATERIALS AND METHODS: ASL was performed using a background-suppressed single-section flow-alternating inversion recovery (FAIR) preparation and a single-shot fast spin-echo imaging sequence on a 3.0-T whole body imager. Tumor BF was evaluated for 26 patients with RCC metastatic to the liver, bone, lung, or lymph nodes before VEGF receptor inhibitor therapy. Two cases with tumor size change after treatment were also scanned 1 month after therapy. For validation, kidney cortex BF in five normal volunteers was measured with the same technique and compared with literature values. RESULTS: ASL was successfully performed in all normal volunteers and in 20 of 26 patients. The six failures resulted from a systematic error, which can be avoided in future studies. For normal volunteers, measured kidney cortex BF was 275 +/- 14 mL/min/100 g, a value consistent with the literature. ASL determined tumor BF averaged across tumor volume and subjects was 194 mL/min/100 g (intersubject SD = 100), resulting in high perfusion signal and conspicuity of lesions. Bright signal was also seen in large vessels and occasionally in bowel. In the two cases studied 1 month after therapy, ASL perfusion changes were consistent with tumor size changes. CONCLUSION: With background suppression, ASL MRI is a feasible method for quantifying BF in patients with renal cell carcinoma. This technique may be useful for evaluating tumor response to antiangiogenic agents.

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Published In

Acad Radiol

DOI

ISSN

1076-6332

Publication Date

March 2005

Volume

12

Issue

3

Start / End Page

347 / 357

Location

United States

Related Subject Headings

  • Spin Labels
  • Regional Blood Flow
  • Receptors, Vascular Endothelial Growth Factor
  • Pyridines
  • Protein Kinase Inhibitors
  • Phthalazines
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Lymphatic Metastasis
 

Citation

APA
Chicago
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De Bazelaire, C., Rofsky, N. M., Duhamel, G., Michaelson, M. D., George, D., & Alsop, D. C. (2005). Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1). Acad Radiol, 12(3), 347–357. https://doi.org/10.1016/j.acra.2004.12.012
De Bazelaire, Cedric, Neil M. Rofsky, Guillaume Duhamel, M Dror Michaelson, Daniel George, and David C. Alsop. “Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1).Acad Radiol 12, no. 3 (March 2005): 347–57. https://doi.org/10.1016/j.acra.2004.12.012.
De Bazelaire C, Rofsky NM, Duhamel G, Michaelson MD, George D, Alsop DC. Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1). Acad Radiol. 2005 Mar;12(3):347–57.
De Bazelaire, Cedric, et al. “Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1).Acad Radiol, vol. 12, no. 3, Mar. 2005, pp. 347–57. Pubmed, doi:10.1016/j.acra.2004.12.012.
De Bazelaire C, Rofsky NM, Duhamel G, Michaelson MD, George D, Alsop DC. Arterial spin labeling blood flow magnetic resonance imaging for the characterization of metastatic renal cell carcinoma(1). Acad Radiol. 2005 Mar;12(3):347–357.
Journal cover image

Published In

Acad Radiol

DOI

ISSN

1076-6332

Publication Date

March 2005

Volume

12

Issue

3

Start / End Page

347 / 357

Location

United States

Related Subject Headings

  • Spin Labels
  • Regional Blood Flow
  • Receptors, Vascular Endothelial Growth Factor
  • Pyridines
  • Protein Kinase Inhibitors
  • Phthalazines
  • Nuclear Medicine & Medical Imaging
  • Male
  • Magnetic Resonance Imaging
  • Lymphatic Metastasis