Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate.

Journal Article (Journal Article)

Prostate cancer is the second most common cause of death from cancer in U.S. men, and advanced, hormone-refractory disease is characterized by painful osteoblastic bone metastases. Endothelin-1, more commonly known as a potent vasoconstrictor, is a normal ejaculate protein that also stimulates osteoblasts. We show here that plasma immunoreactive endothelin concentrations are significantly elevated in men with metastatic prostate cancer and that every human prostate cancer cell line tested produces endothelin-1 messenger RNA and secretes immunoreactive endothelin. Exogenous endothelin-1 is a prostate cancer mitogen in vitro and increases alkaline phosphatase activity in new bone formation, indicating that ectopic endothelin-1 may be a mediator of the osteoblastic response of bone to metastatic prostate cancer.

Full Text

Duke Authors

Cited Authors

  • Nelson, JB; Hedican, SP; George, DJ; Reddi, AH; Piantadosi, S; Eisenberger, MA; Simons, JW

Published Date

  • September 1995

Published In

Volume / Issue

  • 1 / 9

Start / End Page

  • 944 - 949

PubMed ID

  • 7585222

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm0995-944


  • eng

Conference Location

  • United States