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Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate.

Publication ,  Journal Article
Nelson, JB; Hedican, SP; George, DJ; Reddi, AH; Piantadosi, S; Eisenberger, MA; Simons, JW
Published in: Nat Med
September 1995

Prostate cancer is the second most common cause of death from cancer in U.S. men, and advanced, hormone-refractory disease is characterized by painful osteoblastic bone metastases. Endothelin-1, more commonly known as a potent vasoconstrictor, is a normal ejaculate protein that also stimulates osteoblasts. We show here that plasma immunoreactive endothelin concentrations are significantly elevated in men with metastatic prostate cancer and that every human prostate cancer cell line tested produces endothelin-1 messenger RNA and secretes immunoreactive endothelin. Exogenous endothelin-1 is a prostate cancer mitogen in vitro and increases alkaline phosphatase activity in new bone formation, indicating that ectopic endothelin-1 may be a mediator of the osteoblastic response of bone to metastatic prostate cancer.

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Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

September 1995

Volume

1

Issue

9

Start / End Page

944 / 949

Location

United States

Related Subject Headings

  • Vasoconstriction
  • Tumor Cells, Cultured
  • Prostatic Neoplasms
  • Pain
  • Osteoblasts
  • Neoplasm Proteins
  • Molecular Sequence Data
  • Middle Aged
  • Male
  • Ischemia
 

Citation

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Nelson, J. B., Hedican, S. P., George, D. J., Reddi, A. H., Piantadosi, S., Eisenberger, M. A., & Simons, J. W. (1995). Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med, 1(9), 944–949. https://doi.org/10.1038/nm0995-944
Nelson, J. B., S. P. Hedican, D. J. George, A. H. Reddi, S. Piantadosi, M. A. Eisenberger, and J. W. Simons. “Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate.Nat Med 1, no. 9 (September 1995): 944–49. https://doi.org/10.1038/nm0995-944.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, et al. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995 Sep;1(9):944–9.
Nelson, J. B., et al. “Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate.Nat Med, vol. 1, no. 9, Sept. 1995, pp. 944–49. Pubmed, doi:10.1038/nm0995-944.
Nelson JB, Hedican SP, George DJ, Reddi AH, Piantadosi S, Eisenberger MA, Simons JW. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate. Nat Med. 1995 Sep;1(9):944–949.

Published In

Nat Med

DOI

ISSN

1078-8956

Publication Date

September 1995

Volume

1

Issue

9

Start / End Page

944 / 949

Location

United States

Related Subject Headings

  • Vasoconstriction
  • Tumor Cells, Cultured
  • Prostatic Neoplasms
  • Pain
  • Osteoblasts
  • Neoplasm Proteins
  • Molecular Sequence Data
  • Middle Aged
  • Male
  • Ischemia