Comparison of reduced-intensity hematopoietic cell transplantation with chemotherapy in patients age 60-70 years with acute myelogenous leukemia in first remission.

Journal Article (Clinical Trial;Journal Article)

We compared the outcomes of patients age 60-70 years with acute myelogenous leukemia receiving reduced-intensity allogeneic hematopoietic cell transplantation (HCT) in first remission (CR1) reported to the Center for International Blood and Marrow Research (n = 94) with the outcomes in patients treated with induction and postremission chemotherapy on Cancer and Leukemia Group B protocols (n = 96). All patients included had been in CR1 for at least 4 months. The HCT recipients were slightly younger than the chemotherapy patients (median age, 63 years vs 65 years; P < .001), but there were no significant between-group differences in the proportion with therapy-related leukemia or in different cytogenetic risk groups. Time from diagnosis to CR1 was longer for the HCT recipients (median, 44 days vs 38 days; P = .031). Allogeneic HCT was associated with significantly lower risk of relapse (32% vs 81% at 3 years; P < .001), higher nonrelapse mortality (36% vs 4% at 3 years; P < .001), and longer leukemia-free survival (32% vs 15% at 3 years; P = .001). Although overall survival was longer for HCT recipients, the difference was not statistically significant (37% vs 25% at 3 years; P = .08). Our findings suggest that reduced-intensity conditioning allogeneic HCT in patients age 60-70 with acute myelogenous leukemia in CR1 reduces relapse and improves leukemia-free survival. Strategies that reduce nonrelapse mortality may yield significant improvements in overall survival.

Full Text

Duke Authors

Cited Authors

  • Farag, SS; Maharry, K; Zhang, M-J; Pérez, WS; George, SL; Mrózek, K; DiPersio, J; Bunjes, DW; Marcucci, G; Baer, MR; Cairo, M; Copelan, E; Cutler, CS; Isola, L; Lazarus, HM; Litzow, MR; Marks, DI; Ringdén, O; Rizzieri, DA; Soiffer, R; Larson, RA; Tallman, MS; Bloomfield, CD; Weisdorf, DJ; Acute Leukemia Committee of the Center for International Blood and Marrow Transplant Research and Cancer and Leukemia Group B,

Published Date

  • December 2011

Published In

Volume / Issue

  • 17 / 12

Start / End Page

  • 1796 - 1803

PubMed ID

  • 21699879

Pubmed Central ID

  • PMC3817558

Electronic International Standard Serial Number (EISSN)

  • 1523-6536

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2011.06.005


  • eng

Conference Location

  • United States