Evaluation of dose and schedule of L-asparaginase in multidrug therapy of childhood leukemia.

Journal Article (Journal Article)

Six regimens utilizing L-asparaginase in doses of 6,000 IU/M2, 2,000 IU/M2, and 500 IU/M2 in two separate schedules (consecutive and intermittent) along with vincristine and prednisone yielded remarkably similar response rates, approximating 70%, in 306 previously treated children with acute leukemia in relapse. The addition of daunorubicin to one regimen did not alter the response rate. Hypersensitivity reactions occurred in 5% and hyperglycemia in 7%. Lower doses of L-asparaginase significantly reduced the hypersensitivity rate but no such pattern was noted for hyperglycemia. A history of prior resistance to prednisone and vincristine significantly reduced the response rate.

Full Text

Duke Authors

Cited Authors

  • Sutow, WW; George, S; Lowman, JT; Starling, KA; Humphrey, GB; Haggard, ME; Vietti, TJ

Published Date

  • 1976

Published In

Volume / Issue

  • 2 / 4

Start / End Page

  • 387 - 395

PubMed ID

  • 1004382

International Standard Serial Number (ISSN)

  • 0098-1532

Digital Object Identifier (DOI)

  • 10.1002/mpo.2950020405


  • eng

Conference Location

  • United States