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PDEF in prostate cancer.

Publication ,  Journal Article
Sood, AK; Kim, H; Geradts, J
Published in: Prostate
May 1, 2012

Prostate-derived Ets factor (PDEF) is a relatively recently described member of the Ets family of transcription factors. It differs from other family members in its restricted and epithelial-specific expression in normal tissues and its unique DNA-binding motif that together may impart interesting specificity to its function. This communication reviews our current understanding of the expression characteristics of PDEF in normal prostate and in prostate cancer. Also, the biochemical and genetic evidence relating to the role of this transcription factor in prostate cancer is reviewed. Most evidence is consistent with an oncogenic role for PDEF in prostate cancer. Specific observations about the loss of PDEF expression in prostate tumors and its apparent role as a prostate tumor suppressor are also discussed. PDEF is one of the few transcription factors with potential to have a significant impact on the management of prostate cancer. A better understanding of its biology and its role in prostate cancer is urgently needed.

Duke Scholars

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Published In

Prostate

DOI

EISSN

1097-0045

Publication Date

May 1, 2012

Volume

72

Issue

6

Start / End Page

592 / 596

Location

United States

Related Subject Headings

  • Proto-Oncogene Proteins c-ets
  • Prostatic Neoplasms
  • Prostate
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine
  • 1112 Oncology and Carcinogenesis
 

Citation

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Sood, A. K., Kim, H., & Geradts, J. (2012). PDEF in prostate cancer. Prostate, 72(6), 592–596. https://doi.org/10.1002/pros.21461
Sood, Ashwani K., Hyung Kim, and Joseph Geradts. “PDEF in prostate cancer.Prostate 72, no. 6 (May 1, 2012): 592–96. https://doi.org/10.1002/pros.21461.
Sood AK, Kim H, Geradts J. PDEF in prostate cancer. Prostate. 2012 May 1;72(6):592–6.
Sood, Ashwani K., et al. “PDEF in prostate cancer.Prostate, vol. 72, no. 6, May 2012, pp. 592–96. Pubmed, doi:10.1002/pros.21461.
Sood AK, Kim H, Geradts J. PDEF in prostate cancer. Prostate. 2012 May 1;72(6):592–596.
Journal cover image

Published In

Prostate

DOI

EISSN

1097-0045

Publication Date

May 1, 2012

Volume

72

Issue

6

Start / End Page

592 / 596

Location

United States

Related Subject Headings

  • Proto-Oncogene Proteins c-ets
  • Prostatic Neoplasms
  • Prostate
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1114 Paediatrics and Reproductive Medicine
  • 1112 Oncology and Carcinogenesis