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Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ

Publication ,  Journal Article
West, D; Geradts, J; Wahidi, M; Roggli, V
Published in: Human Pathology
January 1, 2011

We report a case of a 56-year-old woman with endobronchial breast cancer metastasis of unusual histology. The patient presented with persistent cough, and a lesion was noted in the left mainstem bronchus on bronchoscopic examination. Biopsy revealed extensive squamous metaplasia of bronchial epithelium along with large, atypical cells exhibiting pagetoid intraepithelial spread within squamous mucosa. Immunohistochemical stains were compatible with a diagnosis of metastatic breast adenocarcinoma with pagetoid spread. To our knowledge, this is the first reported case of endobronchial breast cancer metastasis with this histologic presentation. In this report, we describe the clinical, radiographic, bronchoscopic, histologic, and immunohistochemical characteristics of this case. We provide a brief review of existing literature on endobronchial breast cancer metastasis. In addition, we discuss the principal differential diagnosis of bronchial pagetoid lesions. This report raises awareness of this uncommon manifestation of metastatic breast cancer. © 2011 Elsevier Inc.

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Published In

Human Pathology

DOI

EISSN

1532-8392

ISSN

0046-8177

Publication Date

January 1, 2011

Volume

42

Issue

11

Start / End Page

1819 / 1822

Related Subject Headings

  • Pathology
  • 1103 Clinical Sciences
 

Citation

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Chicago
ICMJE
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West, D., Geradts, J., Wahidi, M., & Roggli, V. (2011). Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ. Human Pathology, 42(11), 1819–1822. https://doi.org/10.1016/j.humpath.2011.03.004
West, D., J. Geradts, M. Wahidi, and V. Roggli. “Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ.” Human Pathology 42, no. 11 (January 1, 2011): 1819–22. https://doi.org/10.1016/j.humpath.2011.03.004.
West D, Geradts J, Wahidi M, Roggli V. Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ. Human Pathology. 2011 Jan 1;42(11):1819–22.
West, D., et al. “Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ.” Human Pathology, vol. 42, no. 11, Jan. 2011, pp. 1819–22. Scopus, doi:10.1016/j.humpath.2011.03.004.
West D, Geradts J, Wahidi M, Roggli V. Endobronchial metastatic breast cancer with pagetoid histology mimicking bronchial pagetoid squamous cell carcinoma in situ. Human Pathology. 2011 Jan 1;42(11):1819–1822.
Journal cover image

Published In

Human Pathology

DOI

EISSN

1532-8392

ISSN

0046-8177

Publication Date

January 1, 2011

Volume

42

Issue

11

Start / End Page

1819 / 1822

Related Subject Headings

  • Pathology
  • 1103 Clinical Sciences