The genomic relationship between primary breast carcinomas and their nodal metastases.
Journal Article (Journal Article)
We screened the whole tumor genome to identify DNA copy number gains and losses that discriminate between primary breast carcinomas (MP) and their nodal metastases (ML). Six candidate genes were confirmed by quantitative PCR to have differentially distributed copy number changes. Three of the genes (ERRγ, DDX6, and TIAM1) were more commonly amplified in nodal metastases. Principal component analysis revealed that MP-ML pairs varied markedly in their genomic divergence. The latter was larger in PR-negative tumors. Nodal metastases may form early or late in the development of breast carcinomas and PR-negative tumors may metastasize earlier or are genomically less stable.
Full Text
Duke Authors
Cited Authors
- Desouki, MM; Liao, S; Conroy, J; Nowak, NJ; Shepherd, L; Gaile, DP; Geradts, J
Published Date
- May 2011
Published In
Volume / Issue
- 29 / 4
Start / End Page
- 300 - 307
PubMed ID
- 21469979
Electronic International Standard Serial Number (EISSN)
- 1532-4192
Digital Object Identifier (DOI)
- 10.3109/07357907.2011.568564
Language
- eng
Conference Location
- England