The genomic relationship between primary breast carcinomas and their nodal metastases.

Journal Article (Journal Article)

We screened the whole tumor genome to identify DNA copy number gains and losses that discriminate between primary breast carcinomas (MP) and their nodal metastases (ML). Six candidate genes were confirmed by quantitative PCR to have differentially distributed copy number changes. Three of the genes (ERRγ, DDX6, and TIAM1) were more commonly amplified in nodal metastases. Principal component analysis revealed that MP-ML pairs varied markedly in their genomic divergence. The latter was larger in PR-negative tumors. Nodal metastases may form early or late in the development of breast carcinomas and PR-negative tumors may metastasize earlier or are genomically less stable.

Full Text

Duke Authors

Cited Authors

  • Desouki, MM; Liao, S; Conroy, J; Nowak, NJ; Shepherd, L; Gaile, DP; Geradts, J

Published Date

  • May 2011

Published In

Volume / Issue

  • 29 / 4

Start / End Page

  • 300 - 307

PubMed ID

  • 21469979

Electronic International Standard Serial Number (EISSN)

  • 1532-4192

Digital Object Identifier (DOI)

  • 10.3109/07357907.2011.568564


  • eng

Conference Location

  • England