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Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study.

Publication ,  Journal Article
O'Brien, KM; Cole, SR; Tse, C-K; Perou, CM; Carey, LA; Foulkes, WD; Dressler, LG; Geradts, J; Millikan, RC
Published in: Clin Cancer Res
December 15, 2010

PURPOSE: Previous research identified differences in breast cancer-specific mortality across 4 intrinsic tumor subtypes: luminal A, luminal B, basal-like, and human epidermal growth factor receptor 2 positive/estrogen receptor negative (HER2(+)/ER(-)). EXPERIMENTAL DESIGN: We used immunohistochemical markers to subtype 1,149 invasive breast cancer patients (518 African American, 631 white) in the Carolina Breast Cancer Study, a population-based study of women diagnosed with breast cancer. Vital status was determined through 2006 using the National Death Index, with median follow-up of 9 years. RESULTS: Cancer subtypes luminal A, luminal B, basal-like, and HER2(+)/ER(-) were distributed as 64%, 11%, 11%, and 5% for whites, and 48%, 8%, 22%, and 7% for African Americans, respectively. Breast cancer mortality was higher for participants with HER2(+)/ER(-) and basal-like breast cancer compared with luminal A and B. African Americans had higher breast cancer-specific mortality than whites, but the effect of race was statistically significant only among women with luminal A breast cancer. However, when compared with the luminal A subtype within racial categories, mortality for participants with basal-like breast cancer was higher among whites (HR = 2.0, 95% CI: 1.2-3.4) than African Americans (HR = 1.5, 95% CI: 1.0-2.4), with the strongest effect seen in postmenopausal white women (HR = 3.9, 95% CI: 1.5-10.0). CONCLUSIONS: Our results confirm the association of basal-like breast cancer with poor prognosis and suggest that basal-like breast cancer is not an inherently more aggressive disease in African American women compared with whites. Additional analyses are needed in populations with known treatment profiles to understand the role of tumor subtypes and race in breast cancer mortality, and in particular our finding that among women with luminal A breast cancer, African Americans have higher mortality than whites.

Duke Scholars

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

December 15, 2010

Volume

16

Issue

24

Start / End Page

6100 / 6110

Location

United States

Related Subject Headings

  • Survival Rate
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Racial Groups
  • Oncology & Carcinogenesis
  • North Carolina
  • Middle Aged
  • Menopause
 

Citation

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Chicago
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MLA
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O’Brien, K. M., Cole, S. R., Tse, C.-K., Perou, C. M., Carey, L. A., Foulkes, W. D., … Millikan, R. C. (2010). Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study. Clin Cancer Res, 16(24), 6100–6110. https://doi.org/10.1158/1078-0432.CCR-10-1533
O’Brien, Katie M., Stephen R. Cole, Chiu-Kit Tse, Charles M. Perou, Lisa A. Carey, William D. Foulkes, Lynn G. Dressler, Joseph Geradts, and Robert C. Millikan. “Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study.Clin Cancer Res 16, no. 24 (December 15, 2010): 6100–6110. https://doi.org/10.1158/1078-0432.CCR-10-1533.
O’Brien KM, Cole SR, Tse C-K, Perou CM, Carey LA, Foulkes WD, et al. Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study. Clin Cancer Res. 2010 Dec 15;16(24):6100–10.
O’Brien, Katie M., et al. “Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study.Clin Cancer Res, vol. 16, no. 24, Dec. 2010, pp. 6100–10. Pubmed, doi:10.1158/1078-0432.CCR-10-1533.
O’Brien KM, Cole SR, Tse C-K, Perou CM, Carey LA, Foulkes WD, Dressler LG, Geradts J, Millikan RC. Intrinsic breast tumor subtypes, race, and long-term survival in the Carolina Breast Cancer Study. Clin Cancer Res. 2010 Dec 15;16(24):6100–6110.

Published In

Clin Cancer Res

DOI

EISSN

1557-3265

Publication Date

December 15, 2010

Volume

16

Issue

24

Start / End Page

6100 / 6110

Location

United States

Related Subject Headings

  • Survival Rate
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • Racial Groups
  • Oncology & Carcinogenesis
  • North Carolina
  • Middle Aged
  • Menopause