Optical assessment of tumor resection margins in the breast.


Journal Article

Breast conserving surgery, in which the breast tumor and surrounding normal tissue are removed, is the primary mode of treatment for invasive and in situ carcinomas of the breast, conditions that affect nearly 200,000 women annually. Of these nearly 200,000 patients who undergo this surgical procedure, between 20-70% of them may undergo additional surgeries to remove tumor that was left behind in the first surgery, due to the lack of intra-operative tools which can detect whether the boundaries of the excised specimens are free from residual cancer. Optical techniques have many attractive attributes which may make them useful tools for intra-operative assessment of breast tumor resection margins. In this manuscript, we discuss clinical design criteria for intra-operative breast tumor margin assessment, and review optical techniques appied to this problem. In addition, we report on the development and clinical testing of quantitative diffuse reflectance imaging (Q-DRI) as a potential solution to this clinical need. Q-DRI is a spectral imaging tool which has been applied to 56 resection margins in 48 patients at Duke University Medical Center. Clear sources of contrast between cancerous and cancer-free resection margins were identified with the device, and resulted in an overall accuracy of 75% in detecting positive margins.

Full Text

Duke Authors

Cited Authors

  • Brown, JQ; Bydlon, TM; Richards, LM; Yu, B; Kennedy, SA; Geradts, J; Wilke, LG; Junker, M; Gallagher, J; Barry, W; Ramanujam, N

Published Date

  • March 1, 2010

Published In

Volume / Issue

  • 16 / 3

Start / End Page

  • 530 - 544

PubMed ID

  • 21544237

Pubmed Central ID

  • 21544237

International Standard Serial Number (ISSN)

  • 1077-260X

Digital Object Identifier (DOI)

  • 10.1109/jstqe.2009.2033257


  • eng

Conference Location

  • United States