Application of a dynamic 4D anthropomorphic breast phantom in contrast-based imaging system optimization: Dual-energy or temporal subtraction?
We previously developed a dynamic 4D anthropomorphic breast phantom, which can be used to optimize contrast-based breast imaging systems, accounting for patient variability and contrast kinetics . In this study we aim to compare the performance of contrast-enhanced mammographic and tomosynthesis imaging protocols followed by temporal subtraction and dual-energy subtraction, qualitatively and quantitatively across a couple of patient models. Signal-difference-to-noise ratio (SDNR) is measured for the six paradigms of contrast enhanced, temporally subtracted, and dual-energy subtracted mammography and tomosynthesis and compared. The results show how the performance is more dependent on the breast model in mammography than in tomosynthesis. Also, it is observed that dual-energy subtraction can be beneficial in mammography, whereas it is not advantageous in tomosynthesis. Lastly, the results suggest that temporal subtraction in general outperforms dual-energy subtraction. © 2012 Springer-Verlag Berlin Heidelberg.
Kiarashi, N; Ghate, SV; Lo, JY; Nolte, LW; Samei, E
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