Evidence-based oral transmucosal fentanyl citrate (OTFC) dosing guidelines.

Journal Article (Journal Article;Review)

OBJECTIVE: To review the evidence for dosing and efficacy of oral transmucosal fentanyl citrate in the management of pain and produce dosing guidelines. DESIGN: The scientific literature pertaining to oral transmucosal fentanyl citrate was reviewed, focusing upon its pharmacology and clinical experience with use in cancer and noncancer pain. Emphasis was upon published, peer-reviewed English language articles. RESULTS: Information was crucially examined and synthesized into guidelines for use and dosing of oral transmucosal fentanyl citrate in cancer and noncancer pain. CONCLUSIONS: Oral transmucosal fentanyl citrate is a potent opioid delivery system, which, when used appropriately, is an effective treatment option for pain. Adherence to guidelines should promote its safe and efficacious use in a variety of clinical pain management settings.

Full Text

Duke Authors

Cited Authors

  • Aronoff, GM; Brennan, MJ; Pritchard, DD; Ginsberg, B

Published Date

  • 2005

Published In

Volume / Issue

  • 6 / 4

Start / End Page

  • 305 - 314

PubMed ID

  • 16083461

International Standard Serial Number (ISSN)

  • 1526-2375

Digital Object Identifier (DOI)

  • 10.1111/j.1526-4637.2005.00045.x


  • eng

Conference Location

  • England