The host response to infection: advancing a novel diagnostic paradigm.

Journal Article (Journal Article)

Capturing the host response by using genomic technologies such as transcriptional profiling provides a new paradigm for classifying and diagnosing infectious disease and for potentially distinguishing infection from other causes of serious respiratory illness. This strategy has been used to define a blood-based RNA signature as a classifier for pandemic H1N1 influenza infection that is distinct from bacterial pneumonia and other inflammatory causes of respiratory disease. To realize the full potential of this approach as a diagnostic test will require additional independent validation of the results and studies to examine the specificity of this signature for viral versus bacterial infection or co-infection.

Full Text

Duke Authors

Cited Authors

  • Ginsburg, GS; Woods, CW

Published Date

  • November 6, 2012

Published In

Volume / Issue

  • 16 / 6

Start / End Page

  • 168 -

PubMed ID

  • 23134694

Pubmed Central ID

  • PMC3672566

Electronic International Standard Serial Number (EISSN)

  • 1466-609X

Digital Object Identifier (DOI)

  • 10.1186/cc11685


  • eng

Conference Location

  • England