Peg-bovine hemoglobin: Safety in a canine dehydrated hypovolemic- hemorrhagic shock model

Journal Article

An initial evaluation of PEG-bHb was performed using a modified hypovolemic shock model. PEG-bHb had a substantially longer intravascular half-life than native Hb and no measurable hemoglobinuria was observed in the canine. PEG-bHb allowed successful resuscitation with an oxygen carrying capacity of 14-22% over that of lactated Ringer's solution.

Duke Authors

Cited Authors

  • Nho, K; Glower, D; Bredehoeft, S; Shankar, H; Shorr, R; Abuchowski, A

Published Date

  • 1992

Published In

  • Biomaterials, Artificial Cells, and Immobilization Biotechnology

Volume / Issue

  • 20 / 2-4

Start / End Page

  • 511 - 524