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NCCN Clinical Practice Guidelines Occult primary.

Publication ,  Journal Article
Ettinger, DS; Agulnik, M; Cates, JMM; Cristea, M; Denlinger, CS; Eaton, KD; Fidias, PM; Gierada, D; Gockerman, JP; Handorf, CR; Iyer, R ...
Published in: J Natl Compr Canc Netw
December 2011

Occult primary tumors, or cancers of unknown primary (CUPs), are defined as histologically proven metastatic malignant tumors whose primary site cannot be identified during pretreatment evaluation. They have a wide variety of clinical presentations and a poor prognosis in most patients. Patients with occult primary tumors often present with general complaints, such as anorexia and weight loss. Clinical absence of primary tumor, early dissemination, aggressiveness, and unpredictability of metastatic pattern are characteristic of these tumors. Life expectancy is very short, with a median survival of 6 to 9 months. In most patients, occult primary tumors are refractory to systemic treatments, and chemotherapy is only palliative and does not significantly improve long-term survival. However, certain clinical presentations of these tumors are associated with a better prognosis. Special pathologic studies can identify subsets of patients with tumor types that are more responsive to chemotherapy. Treatment options should be individualized for this selected group of patients to achieve improved response and survival rates.

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Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

December 2011

Volume

9

Issue

12

Start / End Page

1358 / 1395

Location

United States

Related Subject Headings

  • United States
  • Societies, Medical
  • Practice Guidelines as Topic
  • Oncology & Carcinogenesis
  • Neoplasms, Unknown Primary
  • Molecular Diagnostic Techniques
  • Medical Oncology
  • Male
  • Lymphatic Metastasis
  • Humans
 

Citation

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ICMJE
MLA
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Ettinger, D. S., Agulnik, M., Cates, J. M. M., Cristea, M., Denlinger, C. S., Eaton, K. D., … National Comprehensive Cancer Network, . (2011). NCCN Clinical Practice Guidelines Occult primary. J Natl Compr Canc Netw, 9(12), 1358–1395. https://doi.org/10.6004/jnccn.2011.0117
Ettinger, David S., Mark Agulnik, Justin M. M. Cates, Mihaela Cristea, Crystal S. Denlinger, Keith D. Eaton, Panagiotis M. Fidias, et al. “NCCN Clinical Practice Guidelines Occult primary.J Natl Compr Canc Netw 9, no. 12 (December 2011): 1358–95. https://doi.org/10.6004/jnccn.2011.0117.
Ettinger DS, Agulnik M, Cates JMM, Cristea M, Denlinger CS, Eaton KD, et al. NCCN Clinical Practice Guidelines Occult primary. J Natl Compr Canc Netw. 2011 Dec;9(12):1358–95.
Ettinger, David S., et al. “NCCN Clinical Practice Guidelines Occult primary.J Natl Compr Canc Netw, vol. 9, no. 12, Dec. 2011, pp. 1358–95. Pubmed, doi:10.6004/jnccn.2011.0117.
Ettinger DS, Agulnik M, Cates JMM, Cristea M, Denlinger CS, Eaton KD, Fidias PM, Gierada D, Gockerman JP, Handorf CR, Iyer R, Lenzi R, Phay J, Rashid A, Saltz L, Shulman LN, Smerage JB, Varadhachary GR, Zager JS, Zhen WK, National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines Occult primary. J Natl Compr Canc Netw. 2011 Dec;9(12):1358–1395.

Published In

J Natl Compr Canc Netw

DOI

EISSN

1540-1413

Publication Date

December 2011

Volume

9

Issue

12

Start / End Page

1358 / 1395

Location

United States

Related Subject Headings

  • United States
  • Societies, Medical
  • Practice Guidelines as Topic
  • Oncology & Carcinogenesis
  • Neoplasms, Unknown Primary
  • Molecular Diagnostic Techniques
  • Medical Oncology
  • Male
  • Lymphatic Metastasis
  • Humans