The radiographic diagnosis and treatment of paraneoplastic central nervous system disease.

Journal Article (Journal Article;Review)

Paraneoplastic nervous system syndromes are being identified with increasing frequency because of greater physician awareness and the availability of serodiagnostic tests for some syndromes. Frequently, paraneoplastic syndromes develop in the setting of an indolent, limited stage, or otherwise occult malignancy. As a result, the paraneoplastic disorder often becomes the most disabling part of a patient's disease. Effective treatment appears to require early identification. For these reasons, the ability to diagnose a paraneoplastic syndrome, follow its course, and treat it successfully are important. The authors describe four patients with neurologic paraneoplastic syndromes and identical magnetic resonance imaging abnormalities. Three patients responded to immunosuppressive or immunomodulatory therapy, and in one, corresponding radiographic improvement was documented. Strategies for early diagnosis and options for treatment of paraneoplastic nervous system disorders are discussed.

Full Text

Duke Authors

Cited Authors

  • Glantz, MJ; Biran, H; Myers, ME; Gockerman, JP; Friedberg, MH

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 73 / 1

Start / End Page

  • 168 - 175

PubMed ID

  • 8275420

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(19940101)73:1<168::aid-cncr2820730129>;2-z


  • eng

Conference Location

  • United States