Oral bisphosphonate compliance and persistence: a matter of choice?

Journal Article (Journal Article;Review)

Compliance to oral bisphosphonates is suboptimal, with negative consequences of increased healthcare utilization and less effective fracture risk reduction. Extending dose interval increased adherence only moderately. We used literature derived from multiple chronic conditions to examine the problem of noncompliance with osteoporosis medication. We reviewed the literature on adherence to osteoporosis medication as well as that across multiple chronic conditions to understand what is known about the cause of the poor adherence. Poor compliance to oral medications is due mostly, not to forgetfulness, but to deliberate choice. Gender differences and style of healthcare management also play a role. Preliminary data suggest psychobehavioral interventions may help to improve motivation. We need to understand better reasons for poor compliance before effective interventions can be developed. Forgetfulness is only a small part of poor compliance. Patient preferences must be considered in medication decision making.

Full Text

Duke Authors

Cited Authors

  • Silverman, SL; Schousboe, JT; Gold, DT

Published Date

  • January 2011

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • 21 - 26

PubMed ID

  • 20458571

Pubmed Central ID

  • PMC3017316

Electronic International Standard Serial Number (EISSN)

  • 1433-2965

Digital Object Identifier (DOI)

  • 10.1007/s00198-010-1274-6


  • eng

Conference Location

  • England