Association between blood spot transforming growth factor-β and patent ductus arteriosus in extremely low-birth weight infants.

Journal Article (Journal Article)

Permanent ductal closure involves anatomic remodeling, in which transforming growth factor (TGF)-β appears to play a role. Our objective was to evaluate the relationship, if any, between blood spot TGF-β on day 3 and day 7 of life and patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. Prospective observational study involving ELBW infants (n = 968) in the National Institute of Child Health and Human Development Neonatal Research Network who had TGF-β measured on filter paper spot blood samples using a Luminex assay. Infants with a PDA (n = 493) were significantly more immature, had lower birth weights, and had higher rates of respiratory distress syndrome than those without PDA (n = 475). TGF-β on days 3 and 7 of life, respectively, were significantly lower among neonates with PDA (median 1,177 pg/ml [range 642-1,896]; median 1,386 pg/ml [range 868-1,913]) compared with others without PDA (median 1,334 pg/ml [range 760-2,064]; median 1,712 pg/ml [range 1,014-2,518 pg/ml]). The significant difference persisted when death or PDA was considered a composite outcome. TGF-β levels were not significantly different among subgroups of infants with PDA who were not treated (n = 51) versus those who were treated medically (n = 283) or by surgical ligation (n = 159). TGF-β was not a significant predictor of death or PDA (day 3 odds ratio [OR] 0.99, 95 % confidence interval [CI] 0.83-1.17; day 7 OR 0.88, 95 % CI 0.74-1.04) on adjusted analyses. Our results suggest that blood spot TGF-β alone is unlikely to be a reliable biomarker of a clinically significant PDA or its responsiveness to treatment.

Full Text

Duke Authors

Cited Authors

  • Natarajan, G; Shankaran, S; McDonald, SA; Das, A; Ehrenkranz, RA; Goldberg, RN; Stoll, BJ; Tyson, JE; Higgins, RD; Schendel, D; Hougaard, DM; Skogstrand, K; Thorsen, P; Carlo, WA

Published Date

  • January 2013

Published In

Volume / Issue

  • 34 / 1

Start / End Page

  • 149 - 154

PubMed ID

  • 22684193

Pubmed Central ID

  • PMC3704212

Electronic International Standard Serial Number (EISSN)

  • 1432-1971

Digital Object Identifier (DOI)

  • 10.1007/s00246-012-0404-7


  • eng

Conference Location

  • United States