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Predictive value of an early amplitude integrated electroencephalogram and neurologic examination.

Publication ,  Journal Article
Shankaran, S; Pappas, A; McDonald, SA; Laptook, AR; Bara, R; Ehrenkranz, RA; Tyson, JE; Goldberg, R; Donovan, EF; Fanaroff, AA; Das, A ...
Published in: Pediatrics
July 2011

OBJECTIVE: To examine the predictive validity of the amplitude integrated electroencephalogram (aEEG) and stage of encephalopathy among infants with hypoxic-ischemic encephalopathy (HIE) eligible for therapeutic whole-body hypothermia. DESIGN: Neonates were eligible for this prospective study if moderate or severe HIE occurred at <6 hours and an aEEG was obtained at <9 hours of age. The primary outcome was death or moderate/severe disability at 18 months. RESULTS: There were 108 infants (71 with moderate HIE and 37 with severe HIE) enrolled in the study. aEEG findings were categorized as normal, with continuous normal voltage (n=12) or discontinuous normal voltage (n=12), or abnormal, with burst suppression (n=22), continuous low voltage (n=26), or flat tracing (n=36). At 18 months, 53 infants (49%) experienced death or disability. Severe HIE and an abnormal aEEG were related to the primary outcome with univariate analysis, whereas severe HIE alone was predictive of outcome with multivariate analysis. Addition of aEEG pattern to HIE stage did not add to the predictive value of the model; the area under the curve changed from 0.72 to 0.75 (P=.19). CONCLUSIONS: The aEEG background pattern did not significantly enhance the value of the stage of encephalopathy at study entry in predicting death and disability among infants with HIE.

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Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

July 2011

Volume

128

Issue

1

Start / End Page

e112 / e120

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prospective Studies
  • Predictive Value of Tests
  • Pediatrics
  • Neurologic Examination
  • Male
  • Infant, Newborn
  • Hypoxia-Ischemia, Brain
  • Humans
  • Follow-Up Studies
 

Citation

APA
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ICMJE
MLA
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Shankaran, S., Pappas, A., McDonald, S. A., Laptook, A. R., Bara, R., Ehrenkranz, R. A., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2011). Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics, 128(1), e112–e120. https://doi.org/10.1542/peds.2010-2036
Shankaran, Seetha, Athina Pappas, Scott A. McDonald, Abbot R. Laptook, Rebecca Bara, Richard A. Ehrenkranz, Jon E. Tyson, et al. “Predictive value of an early amplitude integrated electroencephalogram and neurologic examination.Pediatrics 128, no. 1 (July 2011): e112–20. https://doi.org/10.1542/peds.2010-2036.
Shankaran S, Pappas A, McDonald SA, Laptook AR, Bara R, Ehrenkranz RA, et al. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics. 2011 Jul;128(1):e112–20.
Shankaran, Seetha, et al. “Predictive value of an early amplitude integrated electroencephalogram and neurologic examination.Pediatrics, vol. 128, no. 1, July 2011, pp. e112–20. Pubmed, doi:10.1542/peds.2010-2036.
Shankaran S, Pappas A, McDonald SA, Laptook AR, Bara R, Ehrenkranz RA, Tyson JE, Goldberg R, Donovan EF, Fanaroff AA, Das A, Poole WK, Walsh M, Higgins RD, Welsh C, Salhab W, Carlo WA, Poindexter B, Stoll BJ, Guillet R, Finer NN, Stevenson DK, Bauer CR, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics. 2011 Jul;128(1):e112–e120.

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

July 2011

Volume

128

Issue

1

Start / End Page

e112 / e120

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Prospective Studies
  • Predictive Value of Tests
  • Pediatrics
  • Neurologic Examination
  • Male
  • Infant, Newborn
  • Hypoxia-Ischemia, Brain
  • Humans
  • Follow-Up Studies