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Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial.

Publication ,  Journal Article
Kwon, JM; Guillet, R; Shankaran, S; Laptook, AR; McDonald, SA; Ehrenkranz, RA; Tyson, JE; O'Shea, TM; Goldberg, RN; Donovan, EF; Fanaroff, AA ...
Published in: J Child Neurol
March 2011

It remains controversial as to whether neonatal seizures have additional direct effects on the developing brain separate from the severity of the underlying encephalopathy. Using data collected from infants diagnosed with hypoxic-ischemic encephalopathy, and who were enrolled in an National Institute of Child Health and Human Development trial of hypothermia, we analyzed associations between neonatal clinical seizures and outcomes at 18 months of age. Of the 208 infants enrolled, 102 received whole body hypothermia and 106 were controls. Clinical seizures were generally noted during the first 4 days of life and rarely afterward. When adjustment was made for study treatment and severity of encephalopathy, seizures were not associated with death, or moderate or severe disability, or lower Bayley Mental Development Index scores at 18 months of life. Among infants diagnosed with hypoxic-ischemic encephalopathy, the mortality and morbidity often attributed to neonatal seizures can be better explained by the underlying severity of encephalopathy.

Duke Scholars

Published In

J Child Neurol

DOI

EISSN

1708-8283

Publication Date

March 2011

Volume

26

Issue

3

Start / End Page

322 / 328

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Seizures
  • Neurology & Neurosurgery
  • National Institute of Child Health and Human Development (U.S.)
  • Male
  • Infant
  • Hypoxia-Ischemia, Brain
  • Hypothermia, Induced
 

Citation

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ICMJE
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Kwon, J. M., Guillet, R., Shankaran, S., Laptook, A. R., McDonald, S. A., Ehrenkranz, R. A., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, . (2011). Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial. J Child Neurol, 26(3), 322–328. https://doi.org/10.1177/0883073810380915
Kwon, Jennifer M., Ronnie Guillet, Seetha Shankaran, Abbot R. Laptook, Scott A. McDonald, Richard A. Ehrenkranz, Jon E. Tyson, et al. “Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial.J Child Neurol 26, no. 3 (March 2011): 322–28. https://doi.org/10.1177/0883073810380915.
Kwon JM, Guillet R, Shankaran S, Laptook AR, McDonald SA, Ehrenkranz RA, Tyson JE, O’Shea TM, Goldberg RN, Donovan EF, Fanaroff AA, Poole WK, Higgins RD, Walsh MC, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial. J Child Neurol. 2011 Mar;26(3):322–328.
Journal cover image

Published In

J Child Neurol

DOI

EISSN

1708-8283

Publication Date

March 2011

Volume

26

Issue

3

Start / End Page

322 / 328

Location

United States

Related Subject Headings

  • United States
  • Treatment Outcome
  • Time Factors
  • Seizures
  • Neurology & Neurosurgery
  • National Institute of Child Health and Human Development (U.S.)
  • Male
  • Infant
  • Hypoxia-Ischemia, Brain
  • Hypothermia, Induced