Clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial.

Journal Article (Clinical Trial;Journal Article)

It remains controversial as to whether neonatal seizures have additional direct effects on the developing brain separate from the severity of the underlying encephalopathy. Using data collected from infants diagnosed with hypoxic-ischemic encephalopathy, and who were enrolled in an National Institute of Child Health and Human Development trial of hypothermia, we analyzed associations between neonatal clinical seizures and outcomes at 18 months of age. Of the 208 infants enrolled, 102 received whole body hypothermia and 106 were controls. Clinical seizures were generally noted during the first 4 days of life and rarely afterward. When adjustment was made for study treatment and severity of encephalopathy, seizures were not associated with death, or moderate or severe disability, or lower Bayley Mental Development Index scores at 18 months of life. Among infants diagnosed with hypoxic-ischemic encephalopathy, the mortality and morbidity often attributed to neonatal seizures can be better explained by the underlying severity of encephalopathy.

Full Text

Duke Authors

Cited Authors

  • Kwon, JM; Guillet, R; Shankaran, S; Laptook, AR; McDonald, SA; Ehrenkranz, RA; Tyson, JE; O'Shea, TM; Goldberg, RN; Donovan, EF; Fanaroff, AA; Poole, WK; Higgins, RD; Walsh, MC; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network,

Published Date

  • March 2011

Published In

Volume / Issue

  • 26 / 3

Start / End Page

  • 322 - 328

PubMed ID

  • 20921569

Pubmed Central ID

  • PMC3290332

Electronic International Standard Serial Number (EISSN)

  • 1708-8283

Digital Object Identifier (DOI)

  • 10.1177/0883073810380915


  • eng

Conference Location

  • United States