Host genetics and HIV-1: the final phase?

Published

Journal Article (Review)

This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.

Full Text

Cited Authors

  • Fellay, J; Shianna, KV; Telenti, A; Goldstein, DB

Published Date

  • October 14, 2010

Published In

Volume / Issue

  • 6 / 10

Start / End Page

  • e1001033 -

PubMed ID

  • 20976252

Pubmed Central ID

  • 20976252

Electronic International Standard Serial Number (EISSN)

  • 1553-7374

International Standard Serial Number (ISSN)

  • 1553-7366

Digital Object Identifier (DOI)

  • 10.1371/journal.ppat.1001033

Language

  • eng