Whole genome association studies in complex diseases: where do we stand?

Published

Journal Article (Review)

Hundreds of genome-wide association studies have been performed in recent years in order to try to identify common variants that associate with complex disease. These have met with varying success. Some of the strongest effects of common variants have been found in late-onset diseases and in drug response. The major histocompatibility complex has also shown very strong association with a variety of disorders. Although there have been some notable success stories in neuropsychiatric genetics, on the whole, common variation has explained little of the high heritability of these traits. In contrast, early studies of rare copy number variants have led rapidly to a number of genes and loci that strongly associate with neuropsychiatric disorders. It is likely that the use of whole-genome sequencing to extend the study of rare variation in neuropsychiatry will greatly advance our understanding of neuropsychiatric genetics.

Full Text

Cited Authors

  • Need, AC; Goldstein, DB

Published Date

  • January 2010

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 37 - 46

PubMed ID

  • 20373665

Pubmed Central ID

  • 20373665

Electronic International Standard Serial Number (EISSN)

  • 1958-5969

International Standard Serial Number (ISSN)

  • 1294-8322

Language

  • eng