Genetics of epilepsy: epilepsy research foundation workshop report.


Journal Article

The Sixth Epilepsy Research Foundation workshop, held in Oxford in March 2006, brought together basic scientists, geneticists, epidemiologists, statisticians, pharmacologists and clinicians to consider progress, issues and strategies for harnessing genetics to improve the understanding and treatment of the epilepsies. General principles were considered, including the fundamental importance of clear study design, adequate patient numbers, defi ned phenotypes, robust statistical data handling, and follow-up of genetic discoveries. Topics where some progress had been made were considered including chromosomal abnormalities, neurodevelopment, hippocampal sclerosis, juvenile myoclonic epilepsy, focal cortical dysplasia and pharmacogenetics. The ethical aspects of epilepsy genetics were reviewed. Principles and limitations of collaboration were discussed. Presentations and their matched discussions are produced here. There was optimism that further genetic research in epilepsy was not only feasible, but might lead to improvements in the lives of people with epilepsy.

Full Text

Cited Authors

  • Sisodiya, S; Cross, JH; Blümcke, I; Chadwick, D; Craig, J; Crino, PB; Debenham, P; Delanty, N; Elmslie, F; Gardiner, M; Golden, J; Goldstein, D; Greenberg, DA; Guerrini, R; Hanna, M; Harris, J; Harrison, P; Johnson, MR; Kirov, G; Kullman, DM; Makoff, A; Marini, C; Nabbout, R; Nashef, L; Noebels, JL; Ottman, R; Pirmohamed, M; Pitkänen, A; Scheffer, I; Shorvon, S; Sills, G; Wood, N; Zuberi, S

Published Date

  • June 2007

Published In

Volume / Issue

  • 9 / 2

Start / End Page

  • 194 - 236

PubMed ID

  • 17525034

Pubmed Central ID

  • 17525034

Electronic International Standard Serial Number (EISSN)

  • 1950-6945

International Standard Serial Number (ISSN)

  • 1294-9361

Digital Object Identifier (DOI)

  • 10.1684/epd.2007.0107


  • eng