Skip to main content
Journal cover image

Ancient and recent positive selection transformed opioid cis-regulation in humans.

Publication ,  Journal Article
Rockman, MV; Hahn, MW; Soranzo, N; Zimprich, F; Goldstein, DB; Wray, GA
Published in: PLoS biology
December 2005

Changes in the cis-regulation of neural genes likely contributed to the evolution of our species' unique attributes, but evidence of a role for natural selection has been lacking. We found that positive natural selection altered the cis-regulation of human prodynorphin, the precursor molecule for a suite of endogenous opioids and neuropeptides with critical roles in regulating perception, behavior, and memory. Independent lines of phylogenetic and population genetic evidence support a history of selective sweeps driving the evolution of the human prodynorphin promoter. In experimental assays of chimpanzee-human hybrid promoters, the selected sequence increases transcriptional inducibility. The evidence for a change in the response of the brain's natural opioids to inductive stimuli points to potential human-specific characteristics favored during evolution. In addition, the pattern of linked nucleotide and microsatellite variation among and within modern human populations suggests that recent selection, subsequent to the fixation of the human-specific mutations and the peopling of the globe, has favored different prodynorphin cis-regulatory alleles in different parts of the world.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS biology

DOI

EISSN

1545-7885

ISSN

1544-9173

Publication Date

December 2005

Volume

3

Issue

12

Start / End Page

e387

Related Subject Headings

  • Sequence Alignment
  • Selection, Genetic
  • Protein Precursors
  • Promoter Regions, Genetic
  • Phylogeny
  • Narcotics
  • Mutation
  • Molecular Sequence Data
  • Humans
  • Genetic Variation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rockman, M. V., Hahn, M. W., Soranzo, N., Zimprich, F., Goldstein, D. B., & Wray, G. A. (2005). Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS Biology, 3(12), e387. https://doi.org/10.1371/journal.pbio.0030387
Rockman, Matthew V., Matthew W. Hahn, Nicole Soranzo, Fritz Zimprich, David B. Goldstein, and Gregory A. Wray. “Ancient and recent positive selection transformed opioid cis-regulation in humans.PLoS Biology 3, no. 12 (December 2005): e387. https://doi.org/10.1371/journal.pbio.0030387.
Rockman MV, Hahn MW, Soranzo N, Zimprich F, Goldstein DB, Wray GA. Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS biology. 2005 Dec;3(12):e387.
Rockman, Matthew V., et al. “Ancient and recent positive selection transformed opioid cis-regulation in humans.PLoS Biology, vol. 3, no. 12, Dec. 2005, p. e387. Epmc, doi:10.1371/journal.pbio.0030387.
Rockman MV, Hahn MW, Soranzo N, Zimprich F, Goldstein DB, Wray GA. Ancient and recent positive selection transformed opioid cis-regulation in humans. PLoS biology. 2005 Dec;3(12):e387.
Journal cover image

Published In

PLoS biology

DOI

EISSN

1545-7885

ISSN

1544-9173

Publication Date

December 2005

Volume

3

Issue

12

Start / End Page

e387

Related Subject Headings

  • Sequence Alignment
  • Selection, Genetic
  • Protein Precursors
  • Promoter Regions, Genetic
  • Phylogeny
  • Narcotics
  • Mutation
  • Molecular Sequence Data
  • Humans
  • Genetic Variation