Challenge of coadministering antiretroviral therapy and oral anticoagulants in HIV-positive patients.


Journal Article

With an improved life expectancy, HIV-positive patients now face interactions between antiretroviral therapy and medications for chronic medical problems. One example is thromboembolism and its treatment with oral anticoagulants. To date, there have been 9 case reports documenting drug interactions between oral anticoagulants and antiretroviral agents. We conducted a retrospective case series to better understand the challenges of anticoagulation management in HIV-positive patients receiving antiretroviral therapy. Of the 9 cases evaluated, the median percentage of international normalized ratio (INR) measurements of blood clotting time within the therapeutic range was 28.6%. Of those INRs outside the therapeutic range, 50.5% were subtherapeutic and 21.2% were supratherapeutic. A heightened awareness of the potential difficulty in achieving adequate anticoagulation in patients on antiretroviral regimens is warranted.

Full Text

Duke Authors

Cited Authors

  • Goldstein, KM; Gluckman, S; Mounzer, K

Published Date

  • September 2008

Published In

Volume / Issue

  • 18 / 9

Start / End Page

  • 480 - 489

PubMed ID

  • 18828233

Pubmed Central ID

  • 18828233

International Standard Serial Number (ISSN)

  • 1053-0894


  • eng

Conference Location

  • United States