Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms.

Journal Article (Journal Article)

zeta-Crystallin is a lens protein that has been associated with autosomal dominant congenital cataracts in guinea pigs and thus is a candidate for human congenital cataracts. We have assigned the zeta-crystallin gene (CRYZ) to human chromosome 1 using a Southern panel of 17 human-mouse somatic cell hybrids and regionally localized it to 1p22-p31 by fluorescence in situ hybridization. Five restriction fragment length polymorphisms were identified by analyzing the DNA from 10 unrelated, unaffected individuals. Our results will permit evaluation of its role in human cataractogenesis.

Full Text

Duke Authors

Cited Authors

  • Heinzmann, C; Kojis, TL; Gonzalez, P; Rao, PV; Zigler, JS; Polymeropoulos, MH; Klisak, I; Sparkes, RS; Mohandas, T; Bateman, JB

Published Date

  • September 15, 1994

Published In

Volume / Issue

  • 23 / 2

Start / End Page

  • 403 - 407

PubMed ID

  • 7835889

International Standard Serial Number (ISSN)

  • 0888-7543

Digital Object Identifier (DOI)

  • 10.1006/geno.1994.1516


  • eng

Conference Location

  • United States