Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms.
Publication
, Journal Article
Heinzmann, C; Kojis, TL; Gonzalez, P; Rao, PV; Zigler, JS; Polymeropoulos, MH; Klisak, I; Sparkes, RS; Mohandas, T; Bateman, JB
Published in: Genomics
September 15, 1994
zeta-Crystallin is a lens protein that has been associated with autosomal dominant congenital cataracts in guinea pigs and thus is a candidate for human congenital cataracts. We have assigned the zeta-crystallin gene (CRYZ) to human chromosome 1 using a Southern panel of 17 human-mouse somatic cell hybrids and regionally localized it to 1p22-p31 by fluorescence in situ hybridization. Five restriction fragment length polymorphisms were identified by analyzing the DNA from 10 unrelated, unaffected individuals. Our results will permit evaluation of its role in human cataractogenesis.
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Published In
Genomics
DOI
ISSN
0888-7543
Publication Date
September 15, 1994
Volume
23
Issue
2
Start / End Page
403 / 407
Location
United States
Related Subject Headings
- Polymorphism, Restriction Fragment Length
- Mice
- In Situ Hybridization, Fluorescence
- Hybrid Cells
- Humans
- Guinea Pigs
- Genetics & Heredity
- Genetic Linkage
- Crystallins
- Chromosomes, Human, Pair 1
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Heinzmann, C., Kojis, T. L., Gonzalez, P., Rao, P. V., Zigler, J. S., Polymeropoulos, M. H., … Bateman, J. B. (1994). Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. Genomics, 23(2), 403–407. https://doi.org/10.1006/geno.1994.1516
Heinzmann, C., T. L. Kojis, P. Gonzalez, P. V. Rao, J. S. Zigler, M. H. Polymeropoulos, I. Klisak, R. S. Sparkes, T. Mohandas, and J. B. Bateman. “Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms.” Genomics 23, no. 2 (September 15, 1994): 403–7. https://doi.org/10.1006/geno.1994.1516.
Heinzmann C, Kojis TL, Gonzalez P, Rao PV, Zigler JS, Polymeropoulos MH, et al. Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. Genomics. 1994 Sep 15;23(2):403–7.
Heinzmann, C., et al. “Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms.” Genomics, vol. 23, no. 2, Sept. 1994, pp. 403–07. Pubmed, doi:10.1006/geno.1994.1516.
Heinzmann C, Kojis TL, Gonzalez P, Rao PV, Zigler JS, Polymeropoulos MH, Klisak I, Sparkes RS, Mohandas T, Bateman JB. Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. Genomics. 1994 Sep 15;23(2):403–407.
Published In
Genomics
DOI
ISSN
0888-7543
Publication Date
September 15, 1994
Volume
23
Issue
2
Start / End Page
403 / 407
Location
United States
Related Subject Headings
- Polymorphism, Restriction Fragment Length
- Mice
- In Situ Hybridization, Fluorescence
- Hybrid Cells
- Humans
- Guinea Pigs
- Genetics & Heredity
- Genetic Linkage
- Crystallins
- Chromosomes, Human, Pair 1