Digital subtraction pulmonary angiography was performed in 14 patients suspected of having pulmonary embolism. In 13 of 14, useful clinical information was obtained. Four patients were found to have pulmonary emboli. In nine patients, digital subtraction angiography was performed through pulmonary artery catheters already in place for monitoring critically ill patients. Conventional angiography in nine patients confirmed the findings by digital angiography. This initial experience suggests that digital subtraction pulmonary angiography provides adequate image quality in certain circumstances with several advantages over conventional angiography.