Protein tyrosine phosphatases in disease processes

Journal Article (Journal Article)

Given the importance of tyrosine phosphorylation of proteins in signalling pathways, it is perhaps not surprising that protein tyrosine phosphatases (PTPs) are involved in the pathogenesis of certain human diseases. A PTP produced by the Yersinia bacteria (which can cause bubonic plague, septicemia and enteric diseases) is thought to be used as a 'weapon' against host cell functions. In addition, dysfunction of cells' endogenous PTPs may contribute to defective immune function, to cancer and to diabetes. © 1994.

Full Text

Duke Authors

Cited Authors

  • Ninfa, EG; Dixon, JE

Published Date

  • January 1, 1994

Published In

Volume / Issue

  • 4 / 12

Start / End Page

  • 427 - 430

International Standard Serial Number (ISSN)

  • 0962-8924

Digital Object Identifier (DOI)

  • 10.1016/0962-8924(94)90103-1

Citation Source

  • Scopus