Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.
We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.
Gretarsdottir, S; Baas, AF; Thorleifsson, G; Holm, H; den Heijer, M; de Vries, J-PPM; Kranendonk, SE; Zeebregts, CJAM; van Sterkenburg, SM; Geelkerken, RH; van Rij, AM; Williams, MJA; Boll, APM; Kostic, JP; Jonasdottir, A; Jonasdottir, A; Walters, GB; Masson, G; Sulem, P; Saemundsdottir, J; Mouy, M; Magnusson, KP; Tromp, G; Elmore, JR; Sakalihasan, N; Limet, R; Defraigne, J-O; Ferrell, RE; Ronkainen, A; Ruigrok, YM; Wijmenga, C; Grobbee, DE; Shah, SH; Granger, CB; Quyyumi, AA; Vaccarino, V; Patel, RS; Zafari, AM; Levey, AI; Austin, H; Girelli, D; Pignatti, PF; Olivieri, O; Martinelli, N; Malerba, G; Trabetti, E; Becker, LC; Becker, DM; Reilly, MP; Rader, DJ; Mueller, T; Dieplinger, B; Haltmayer, M; Urbonavicius, S; Lindblad, B; Gottsäter, A; Gaetani, E; Pola, R; Wells, P; Rodger, M; Forgie, M; Langlois, N; Corral, J; Vicente, V; Fontcuberta, J; España, F; Grarup, N; Jørgensen, T; Witte, DR; Hansen, T; Pedersen, O; Aben, KK; de Graaf, J; Holewijn, S; Folkersen, L; Franco-Cereceda, A; Eriksson, P; Collier, DA; Stefansson, H; Steinthorsdottir, V; Rafnar, T; Valdimarsson, EM; Magnadottir, HB; Sveinbjornsdottir, S; Olafsson, I; Magnusson, MK; Palmason, R; Haraldsdottir, V; Andersen, K; Onundarson, PT; Thorgeirsson, G; Kiemeney, LA; Powell, JT; Carey, DJ; Kuivaniemi, H; Lindholt, JS; Jones, GT; Kong, A; Blankensteijn, JD; Matthiasson, SE; Thorsteinsdottir, U; Stefansson, K
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