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Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.

Publication ,  Journal Article
Gretarsdottir, S; Baas, AF; Thorleifsson, G; Holm, H; den Heijer, M; de Vries, J-PPM; Kranendonk, SE; Zeebregts, CJAM; van Sterkenburg, SM ...
Published in: Nat Genet
August 2010

We performed a genome-wide association study on 1,292 individuals with abdominal aortic aneurysms (AAAs) and 30,503 controls from Iceland and The Netherlands, with a follow-up of top markers in up to 3,267 individuals with AAAs and 7,451 controls. The A allele of rs7025486 on 9q33 was found to associate with AAA, with an odds ratio (OR) of 1.21 and P = 4.6 x 10(-10). In tests for association with other vascular diseases, we found that rs7025486[A] is associated with early onset myocardial infarction (OR = 1.18, P = 3.1 x 10(-5)), peripheral arterial disease (OR = 1.14, P = 3.9 x 10(-5)) and pulmonary embolism (OR = 1.20, P = 0.00030), but not with intracranial aneurysm or ischemic stroke. No association was observed between rs7025486[A] and common risk factors for arterial and venous diseases-that is, smoking, lipid levels, obesity, type 2 diabetes and hypertension. Rs7025486 is located within DAB2IP, which encodes an inhibitor of cell growth and survival.

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Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

August 2010

Volume

42

Issue

8

Start / End Page

692 / 697

Location

United States

Related Subject Headings

  • ras GTPase-Activating Proteins
  • Risk Factors
  • Odds Ratio
  • Netherlands
  • Myocardial Infarction
  • Iceland
  • Hypertension
  • Humans
  • Genome-Wide Association Study
  • Disease Susceptibility
 

Citation

APA
Chicago
ICMJE
MLA
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Gretarsdottir, S., Baas, A. F., Thorleifsson, G., Holm, H., den Heijer, M., de Vries, J.-P., … Stefansson, K. (2010). Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet, 42(8), 692–697. https://doi.org/10.1038/ng.622
Gretarsdottir, Solveig, Annette F. Baas, Gudmar Thorleifsson, Hilma Holm, Martin den Heijer, Jean-Paul P. M. de Vries, Steef E. Kranendonk, et al. “Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.Nat Genet 42, no. 8 (August 2010): 692–97. https://doi.org/10.1038/ng.622.
Gretarsdottir S, Baas AF, Thorleifsson G, Holm H, den Heijer M, de Vries J-PPM, et al. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet. 2010 Aug;42(8):692–7.
Gretarsdottir, Solveig, et al. “Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.Nat Genet, vol. 42, no. 8, Aug. 2010, pp. 692–97. Pubmed, doi:10.1038/ng.622.
Gretarsdottir S, Baas AF, Thorleifsson G, Holm H, den Heijer M, de Vries J-PPM, Kranendonk SE, Zeebregts CJAM, van Sterkenburg SM, Geelkerken RH, van Rij AM, Williams MJA, Boll APM, Kostic JP, Jonasdottir A, Walters GB, Masson G, Sulem P, Saemundsdottir J, Mouy M, Magnusson KP, Tromp G, Elmore JR, Sakalihasan N, Limet R, Defraigne J-O, Ferrell RE, Ronkainen A, Ruigrok YM, Wijmenga C, Grobbee DE, Shah SH, Granger CB, Quyyumi AA, Vaccarino V, Patel RS, Zafari AM, Levey AI, Austin H, Girelli D, Pignatti PF, Olivieri O, Martinelli N, Malerba G, Trabetti E, Becker LC, Becker DM, Reilly MP, Rader DJ, Mueller T, Dieplinger B, Haltmayer M, Urbonavicius S, Lindblad B, Gottsäter A, Gaetani E, Pola R, Wells P, Rodger M, Forgie M, Langlois N, Corral J, Vicente V, Fontcuberta J, España F, Grarup N, Jørgensen T, Witte DR, Hansen T, Pedersen O, Aben KK, de Graaf J, Holewijn S, Folkersen L, Franco-Cereceda A, Eriksson P, Collier DA, Stefansson H, Steinthorsdottir V, Rafnar T, Valdimarsson EM, Magnadottir HB, Sveinbjornsdottir S, Olafsson I, Magnusson MK, Palmason R, Haraldsdottir V, Andersen K, Onundarson PT, Thorgeirsson G, Kiemeney LA, Powell JT, Carey DJ, Kuivaniemi H, Lindholt JS, Jones GT, Kong A, Blankensteijn JD, Matthiasson SE, Thorsteinsdottir U, Stefansson K. Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet. 2010 Aug;42(8):692–697.

Published In

Nat Genet

DOI

EISSN

1546-1718

Publication Date

August 2010

Volume

42

Issue

8

Start / End Page

692 / 697

Location

United States

Related Subject Headings

  • ras GTPase-Activating Proteins
  • Risk Factors
  • Odds Ratio
  • Netherlands
  • Myocardial Infarction
  • Iceland
  • Hypertension
  • Humans
  • Genome-Wide Association Study
  • Disease Susceptibility