Integrating ancillary studies in a large clinical trial: the design and rationale of the APEX library.

Published

Journal Article

The APEX library was a coordinated and integrated set of ancillary analyses and substudies that were a part of the large APEX-AMI trial. The library included electrocardiogram, angiographic, blood biomarker, genetics, and MRI components. Operationally, the goals and administration of the APEX library were developed concurrently with the design of the parent trial. The goal recruitment in the library was met due to this approach. These data will provide important insights into the pathobiology of acute myocardial infarction and the relationships between inflammation, thrombosis, genetics, and classic clinical markers from angiograms, electrocardiograms, and patient demographics. In conclusion, the APEX library is an example of successful collaboration among academic trial leaders, site investigators, and pharmaceutical sponsors. The operational paradigm of this effort should be considered in future investigations so that important advances in clinical care of disease can be realized efficiently.

Full Text

Duke Authors

Cited Authors

  • Mahaffey, KW; Reist, CJ; Fu, Y; Brener, SJ; Theroux, P; Patel, MR; Stebbins, A; Westerhout, CM; Todaro, TG; Adams, PX; Granger, CB; Armstrong, PW; APEX Library Study Investigators,

Published Date

  • November 2008

Published In

Volume / Issue

  • 29 / 6

Start / End Page

  • 887 - 895

PubMed ID

  • 18644468

Pubmed Central ID

  • 18644468

Electronic International Standard Serial Number (EISSN)

  • 1559-2030

Digital Object Identifier (DOI)

  • 10.1016/j.cct.2008.06.003

Language

  • eng

Conference Location

  • United States