The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm.

Published

Journal Article

Recently, two common sequence variants on 9p21, tagged by rs10757278-G and rs10811661-T, were reported to be associated with coronary artery disease (CAD) and type 2 diabetes (T2D), respectively. We proceeded to further investigate the contributions of these variants to arterial diseases and T2D. Here we report that rs10757278-G is associated with, in addition to CAD, abdominal aortic aneurysm (AAA; odds ratio (OR) = 1.31, P = 1.2 x 10(-12)) and intracranial aneurysm (OR = 1.29, P = 2.5 x 10(-6)), but not with T2D. This variant is the first to be described that affects the risk of AAA and intracranial aneurysm in many populations. The association of rs10811661-T to T2D replicates in our samples, but the variant does not associate with any of the five arterial diseases examined. These findings extend our insight into the role of the sequence variant tagged by rs10757278-G and show that it is not confined to atherosclerotic diseases.

Full Text

Duke Authors

Cited Authors

  • Helgadottir, A; Thorleifsson, G; Magnusson, KP; Grétarsdottir, S; Steinthorsdottir, V; Manolescu, A; Jones, GT; Rinkel, GJE; Blankensteijn, JD; Ronkainen, A; Jääskeläinen, JE; Kyo, Y; Lenk, GM; Sakalihasan, N; Kostulas, K; Gottsäter, A; Flex, A; Stefansson, H; Hansen, T; Andersen, G; Weinsheimer, S; Borch-Johnsen, K; Jorgensen, T; Shah, SH; Quyyumi, AA; Granger, CB; Reilly, MP; Austin, H; Levey, AI; Vaccarino, V; Palsdottir, E; Walters, GB; Jonsdottir, T; Snorradottir, S; Magnusdottir, D; Gudmundsson, G; Ferrell, RE; Sveinbjornsdottir, S; Hernesniemi, J; Niemelä, M; Limet, R; Andersen, K; Sigurdsson, G; Benediktsson, R; Verhoeven, ELG; Teijink, JAW; Grobbee, DE; Rader, DJ; Collier, DA; Pedersen, O; Pola, R; Hillert, J; Lindblad, B; Valdimarsson, EM; Magnadottir, HB; Wijmenga, C; Tromp, G; Baas, AF; Ruigrok, YM; van Rij, AM; Kuivaniemi, H; Powell, JT; Matthiasson, SE; Gulcher, JR; Thorgeirsson, G; Kong, A; Thorsteinsdottir, U; Stefansson, K

Published Date

  • February 2008

Published In

Volume / Issue

  • 40 / 2

Start / End Page

  • 217 - 224

PubMed ID

  • 18176561

Pubmed Central ID

  • 18176561

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng.72

Language

  • eng