A common variant on chromosome 9p21 affects the risk of myocardial infarction.


Journal Article

The global endemic of cardiovascular diseases calls for improved risk assessment and treatment. Here, we describe an association between myocardial infarction (MI) and a common sequence variant on chromosome 9p21. This study included a total of 4587 cases and 12,767 controls. The identified variant, adjacent to the tumor suppressor genes CDKN2A and CDKN2B, was associated with the disease with high significance. Approximately 21% of individuals in the population are homozygous for this variant, and their estimated risk of suffering myocardial infarction is 1.64 times as great as that of noncarriers. The corresponding risk is 2.02 times as great for early-onset cases. The population attributable risk is 21% for MI in general and 31% for early-onset cases.

Full Text

Duke Authors

Cited Authors

  • Helgadottir, A; Thorleifsson, G; Manolescu, A; Gretarsdottir, S; Blondal, T; Jonasdottir, A; Jonasdottir, A; Sigurdsson, A; Baker, A; Palsson, A; Masson, G; Gudbjartsson, DF; Magnusson, KP; Andersen, K; Levey, AI; Backman, VM; Matthiasdottir, S; Jonsdottir, T; Palsson, S; Einarsdottir, H; Gunnarsdottir, S; Gylfason, A; Vaccarino, V; Hooper, WC; Reilly, MP; Granger, CB; Austin, H; Rader, DJ; Shah, SH; Quyyumi, AA; Gulcher, JR; Thorgeirsson, G; Thorsteinsdottir, U; Kong, A; Stefansson, K

Published Date

  • June 8, 2007

Published In

Volume / Issue

  • 316 / 5830

Start / End Page

  • 1491 - 1493

PubMed ID

  • 17478679

Pubmed Central ID

  • 17478679

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1142842


  • eng

Conference Location

  • United States