Block and modulation of cardiac Na+ channels by antiarrhythmic drugs, neurotransmitters and hormones.

Journal Article (Journal Article;Review)

The Na+ channel is an important target for the action of antiarrhythmic drugs. Application of contemporary biophysical, biochemical and molecular biological techniques have added considerably to our knowledge of its structure, function, modulation and block by antiarrhythmic drugs. The increased mortality from the use of these drugs for prophylaxis of cardiac arrhythmias has forced a re-evaluation of their use and of the entire pharmacological strategy of arrhythmia management. Gus Grant and David Wendt review recent studies on the block and modulation of cardiac Na+ channels and the place of Na+ channel blockers in future antiarrhythmic drug development.

Full Text

Duke Authors

Cited Authors

  • Grant, AO; Wendt, DJ

Published Date

  • September 1992

Published In

Volume / Issue

  • 13 / 9

Start / End Page

  • 352 - 358

PubMed ID

  • 1356284

International Standard Serial Number (ISSN)

  • 0165-6147

Digital Object Identifier (DOI)

  • 10.1016/0165-6147(92)90108-i


  • eng

Conference Location

  • England