Intracranial catheter for integrated 3D ultrasound imaging & hyperthermia: Feasibility study

Journal Article

In this study, we investigated the feasibility of an intracranial catheter transducer capable of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. We designed and constructed a 12 Fr, integrated matrix and linear array catheter transducer prototype for combined RT3D imaging and heating capability. This dual-mode catheter incorporated 153 matrix array elements and 11 linear array elements, on a 0.2 mm pitch, with a total aperture size of 8.4 mm × 2.3 mm. This array achieved a 3.5°C in vitro temperature rise at a 2 cm focal distance in tissue-mimicking material. The dual-mode catheter prototype was compared with a Siemens 10 Fr AcuNav™ catheter as a gold standard in experiments assessing image quality and therapeutic potential, and both probes were used in a canine brain model to image anatomical structures and color Doppler blood flow and to attempt in vivo heating. © 2009 American Institute of physics.

Full Text

Duke Authors

Cited Authors

  • Herickhoff, CD; Light, ED; Bing, KF; Mukundan, S; Grant, GA; Wolf, PD; Dixon-Tulloch, E; Shih, T; Hsu, SJ; Smith, SW

Published Date

  • July 21, 2009

Published In

Volume / Issue

  • 1113 /

Start / End Page

  • 342 - 346

Electronic International Standard Serial Number (EISSN)

  • 1551-7616

International Standard Serial Number (ISSN)

  • 0094-243X

Digital Object Identifier (DOI)

  • 10.1063/1.3131444

Citation Source

  • Scopus