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Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field.

Publication ,  Journal Article
Grant, G; Cadossi, R; Steinberg, G
Published in: Bioelectromagnetics
1994

There is evidence that electromagnetic stimulation may accelerate the healing of tissue damage following ischemia. We undertook this study to investigate the effects of low frequency pulsed electromagnetic field (PEMF) exposure on cerebral injury in a rabbit model of transient focal ischemia (2 h occlusion followed by 4 h of reperfusion). PEMF exposure (280 V, 75 Hz, IGEA Stimulator) was initiated 10 min after the onset of ischemia and continued throughout reperfusion (six exposed, six controls). Magnetic resonance imaging (MRI) and histology were used to measure the degree of ischemic injury. Exposure to pulsed electromagnetic field attenuated cortical ischemia edema on MRI at the most anterior coronal level by 65% (P < 0.001). On histologic examination, PEMF exposure reduced ischemic neuronal damage in this same cortical area by 69% (P < 0.01) and by 43% (P < 0.05) in the striatum. Preliminary data suggest that exposure to a PEMF of short duration may have implications for the treatment of acute stroke.

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Published In

Bioelectromagnetics

DOI

ISSN

0197-8462

Publication Date

1994

Volume

15

Issue

3

Start / End Page

205 / 216

Location

United States

Related Subject Headings

  • Reperfusion
  • Rabbits
  • Neurons
  • Neostriatum
  • Male
  • Magnetic Resonance Imaging
  • Ischemic Attack, Transient
  • Evoked Potentials, Somatosensory
  • Electromagnetic Fields
  • Cerebrovascular Disorders
 

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Grant, G., Cadossi, R., & Steinberg, G. (1994). Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field. Bioelectromagnetics, 15(3), 205–216. https://doi.org/10.1002/bem.2250150305
Grant, G., R. Cadossi, and G. Steinberg. “Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field.Bioelectromagnetics 15, no. 3 (1994): 205–16. https://doi.org/10.1002/bem.2250150305.
Grant G, Cadossi R, Steinberg G. Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field. Bioelectromagnetics. 1994;15(3):205–16.
Grant, G., et al. “Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field.Bioelectromagnetics, vol. 15, no. 3, 1994, pp. 205–16. Pubmed, doi:10.1002/bem.2250150305.
Grant G, Cadossi R, Steinberg G. Protection against focal cerebral ischemia following exposure to a pulsed electromagnetic field. Bioelectromagnetics. 1994;15(3):205–216.
Journal cover image

Published In

Bioelectromagnetics

DOI

ISSN

0197-8462

Publication Date

1994

Volume

15

Issue

3

Start / End Page

205 / 216

Location

United States

Related Subject Headings

  • Reperfusion
  • Rabbits
  • Neurons
  • Neostriatum
  • Male
  • Magnetic Resonance Imaging
  • Ischemic Attack, Transient
  • Evoked Potentials, Somatosensory
  • Electromagnetic Fields
  • Cerebrovascular Disorders