The Cardiac Safety Research Consortium ECG database.

Published

Journal Article

The Cardiac Safety Research Consortium (CSRC) ECG database was initiated to foster research using anonymized, XML-formatted, digitized ECGs with corresponding descriptive variables from placebo- and positive-control arms of thorough QT studies submitted to the US Food and Drug Administration (FDA) by pharmaceutical sponsors. The database can be expanded to other data that are submitted directly to CSRC from other sources, and currently includes digitized ECGs from patients with genotyped varieties of congenital long-QT syndrome; this congenital long-QT database is also linked to ambulatory electrocardiograms stored in the Telemetric and Holter ECG Warehouse (THEW). Thorough QT data sets are available from CSRC for unblinded development of algorithms for analysis of repolarization and for blinded comparative testing of algorithms developed for the identification of moxifloxacin, as used as a positive control in thorough QT studies. Policies and procedures for access to these data sets are available from CSRC, which has developed tools for statistical analysis of blinded new algorithm performance. A recently approved CSRC project will create a data set for blinded analysis of automated ECG interval measurements, whose initial focus will include comparison of four of the major manufacturers of automated electrocardiographs in the United States. CSRC welcomes application for use of the ECG database for clinical investigation.

Full Text

Duke Authors

Cited Authors

  • Kligfield, P; Green, CL

Published Date

  • November 2012

Published In

Volume / Issue

  • 45 / 6

Start / End Page

  • 690 - 692

PubMed ID

  • 22999491

Pubmed Central ID

  • 22999491

Electronic International Standard Serial Number (EISSN)

  • 1532-8430

International Standard Serial Number (ISSN)

  • 0022-0736

Digital Object Identifier (DOI)

  • 10.1016/j.jelectrocard.2012.07.012

Language

  • eng