Skip to main content
Journal cover image

Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients.

Publication ,  Journal Article
Lehrich, RW; Greenberg, A
Published in: J Intensive Care Med
2012

Hyponatremia in critically ill patients is a common and challenging problem. Increased levels of arginine vasopressin almost always contribute to the etiology. Inhibition of the vasopressin receptor with a vasopressin receptor antagonist (vaptan) is a novel approach to the treatment of hyponatremia. Vaptans are well suited to the treatment of chronic hyponatremia associated with syndrome of inappropriate anti-diuretic hormone secretion (SIADH) and hypervolemic states like cirrhosis or congestive heart failure. No data are available on the use of vaptans in acute hyponatremia, and they are not indicated in hypovolemic hyponatremia. The focus of this review is the treatment of critically ill patients with hyponatremia with vaptans and other measures.

Duke Scholars

Published In

J Intensive Care Med

DOI

EISSN

1525-1489

Publication Date

2012

Volume

27

Issue

4

Start / End Page

207 / 218

Location

United States

Related Subject Headings

  • Tolvaptan
  • Hyponatremia
  • Humans
  • Hormone Antagonists
  • Emergency & Critical Care Medicine
  • Critical Illness
  • Benzazepines
  • Antidiuretic Hormone Receptor Antagonists
  • 1110 Nursing
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lehrich, R. W., & Greenberg, A. (2012). Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients. J Intensive Care Med, 27(4), 207–218. https://doi.org/10.1177/0885066610397016
Lehrich, Ruediger W., and Arthur Greenberg. “Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients.J Intensive Care Med 27, no. 4 (2012): 207–18. https://doi.org/10.1177/0885066610397016.
Lehrich RW, Greenberg A. Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients. J Intensive Care Med. 2012;27(4):207–18.
Lehrich, Ruediger W., and Arthur Greenberg. “Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients.J Intensive Care Med, vol. 27, no. 4, 2012, pp. 207–18. Pubmed, doi:10.1177/0885066610397016.
Lehrich RW, Greenberg A. Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients. J Intensive Care Med. 2012;27(4):207–218.
Journal cover image

Published In

J Intensive Care Med

DOI

EISSN

1525-1489

Publication Date

2012

Volume

27

Issue

4

Start / End Page

207 / 218

Location

United States

Related Subject Headings

  • Tolvaptan
  • Hyponatremia
  • Humans
  • Hormone Antagonists
  • Emergency & Critical Care Medicine
  • Critical Illness
  • Benzazepines
  • Antidiuretic Hormone Receptor Antagonists
  • 1110 Nursing
  • 1103 Clinical Sciences