Normal myocardial function in severe right ventricular volume overload hypertrophy.


Journal Article

Severe left ventricular volume overloading causes myocardial and cellular contractile dysfunction. Whether this is also true for severe right ventricular volume overloading was unknown. We therefore created severe tricuspid regurgitation percutaneously in seven dogs and then observed them for 3.5-4.0 yr. All five surviving operated dogs had severe tricuspid regurgitation and right heart failure, including massive ascites, but they did not have left heart failure. Right ventricular cardiocytes were isolated from these and from normal dogs, and sarcomere mechanics were assessed via laser diffraction. Right ventricular cardiocytes from the tricuspid regurgitation dogs were 20% longer than control cells, but neither the extent (0.171 +/- 0.005 microm) nor the velocity (2.92 +/- 0.12 microm/s) of sarcomere shortening differed from controls (0.179 +/- 0.005 microm and 3.09 +/- 0.11 microm/s, respectively). Thus, despite massive tricuspid regurgitation causing overt right heart failure, intrinsic right ventricular contractile function was normal. This finding for the severely volume-overloaded right ventricle stands in distinct contrast to our finding for the left ventricle severely volume overloaded by mitral regurgitation, wherein intrinsic contractile function is depressed.

Full Text

Duke Authors

Cited Authors

  • Ishibashi, Y; Rembert, JC; Carabello, BA; Nemoto, S; Hamawaki, M; Zile, MR; Greenfield, JC; Cooper, G

Published Date

  • January 2001

Published In

Volume / Issue

  • 280 / 1

Start / End Page

  • H11 - H16

PubMed ID

  • 11123212

Pubmed Central ID

  • 11123212

International Standard Serial Number (ISSN)

  • 0363-6135

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.2001.280.1.H11


  • eng

Conference Location

  • United States