A reproducible model of moderate to severe concentric left ventricular hypertrophy.


Journal Article

A reproducible model for the production of moderate to severe concentric left ventricular hypertrophy has been developed in this laboratory. Coarctation-banding of the ascending aorta was performed successfully in 10 puppies. There were no late deaths related to aortic rupture, and in the dogs surviving for 1 yr no evidence of congestive heart failure was present. A second operative procedure was performed in seven dogs for chronic instrumentation, and all survived. Severe supravalvular aortic stenosis with a marked peak systolic pressure gradient was noted in each dog. Postmortem examination revealed a substantial increase in left ventricular mass and in the ratio of left ventricular to body weight.

Full Text

Duke Authors

Cited Authors

  • Kleinman, LH; Wechsler, AS; Rembert, JC; Fedor, JM; Greenfield, JC

Published Date

  • May 1, 1978

Published In

Volume / Issue

  • 234 / 5

Start / End Page

  • H515 - H519

PubMed ID

  • 148215

Pubmed Central ID

  • 148215

International Standard Serial Number (ISSN)

  • 0002-9513

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.1978.234.5.H515


  • eng

Conference Location

  • United States