Neurogenic influences on the coronary vascular response to ischemia in the awake dog.


Journal Article

The influence of the nervous system on the response of the coronary vessels to ischemia was evaluated by observing the reactive hyperemia subsequent to a 10 second occlusion of the left circumflex coronary artery in 19 awake dogs. Sympathectomy produced by pretreatment with 6-hydroxydopamine, chronic total surgical cardiac denervation, beta-adrenergic blockade with propranolol, and alpha blockade with phentolamine did not significantly after the reactive hyperemic response. Thus cardiac denervation did not impair the ability of the coronary vasculature to respond to a brief ischemic stimulus.

Full Text

Duke Authors

Cited Authors

  • Bache, RJ; Cobb, FR; Ebert, PA; Greenfield, JC

Published Date

  • March 1, 1975

Published In

Volume / Issue

  • 69 / 3

Start / End Page

  • 421 - 428

PubMed ID

  • 1117733

Pubmed Central ID

  • 1117733

International Standard Serial Number (ISSN)

  • 0022-5223


  • eng

Conference Location

  • United States